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Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity.
Hangiu O, Compte M, Dinesen A, Navarro R, Tapia-Galisteo A, Mandrup OA, Erce-Llamazares A, Lázaro-Gorines R, Nehme-Álvarez D, Domínguez-Alonso C, Harwood SL, Alfonso C, Blanco B, Rubio-Pérez L, Jiménez-Reinoso A, Díez-Alonso L, Blanco FJ, Sanz L, Howard KA, Álvarez-Vallina L. Hangiu O, et al. Among authors: howard ka. iScience. 2022 Aug 17;25(9):104958. doi: 10.1016/j.isci.2022.104958. eCollection 2022 Sep 16. iScience. 2022. PMID: 36072551 Free PMC article.
Bioengineered solutions to improve cancer immunotherapies.
Mandrup OA, Howard KA. Mandrup OA, et al. Among authors: howard ka. Ther Deliv. 2021 May;12(5):339-341. doi: 10.4155/tde-2021-0019. Epub 2021 Mar 17. Ther Deliv. 2021. PMID: 33726505 No abstract available.
Identification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design.
Glud EN, Rasmussen M, Zhang Y, Mandrup OA, Salachan PV, Borre M, Sørensen KD, Howard KA. Glud EN, et al. Among authors: howard ka. Br J Cancer. 2022 Dec;127(12):2186-2197. doi: 10.1038/s41416-022-01994-1. Epub 2022 Oct 15. Br J Cancer. 2022. PMID: 36243890 Free PMC article.
An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.
Dinesen A, Andersen VL, Elkhashab M, Pilati D, Bech P, Fuchs E, Samuelsen TR, Winther A, Cai Y, Märcher A, Wall A, Omer M, Nielsen JS, Chudasama V, Baker JR, Gothelf KV, Wengel J, Kjems J, Howard KA. Dinesen A, et al. Among authors: howard ka. Bioconjug Chem. 2024 Feb 21;35(2):214-222. doi: 10.1021/acs.bioconjchem.3c00491. Epub 2024 Jan 17. Bioconjug Chem. 2024. PMID: 38231391
Albumin-based drug delivery: harnessing nature to cure disease.
Larsen MT, Kuhlmann M, Hvam ML, Howard KA. Larsen MT, et al. Among authors: howard ka. Mol Cell Ther. 2016 Feb 27;4:3. doi: 10.1186/s40591-016-0048-8. eCollection 2016. Mol Cell Ther. 2016. PMID: 26925240 Free PMC article. Review.
162 results