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Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.
Lorusso G, Wyss CB, Kuonen F, Vannini N, Billottet C, Duffey N, Pineau R, Lan Q, Wirapati P, Barras D, Tancredi A, Lyck R, Lehr HA, Engelhardt B, Delorenzi M, Bikfalvi A, Rüegg C. Lorusso G, et al. Among authors: wyss cb. Sci Transl Med. 2022 Sep 7;14(661):eaax8933. doi: 10.1126/scitranslmed.aax8933. Epub 2022 Sep 7. Sci Transl Med. 2022. PMID: 36070364
ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier.
Lyck R, Lécuyer MA, Abadier M, Wyss CB, Matti C, Rosito M, Enzmann G, Zeis T, Michel L, García Martín AB, Sallusto F, Gosselet F, Deutsch U, Weiner JA, Schaeren-Wiemers N, Prat A, Engelhardt B. Lyck R, et al. Among authors: wyss cb. J Cereb Blood Flow Metab. 2017 Aug;37(8):2894-2909. doi: 10.1177/0271678X16678639. Epub 2016 Nov 14. J Cereb Blood Flow Metab. 2017. PMID: 28273717 Free PMC article.
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Tang F, Gao R, Jeevan-Raj B, Wyss CB, Kalathur RKR, Piscuoglio S, Ng CKY, Hindupur SK, Nuciforo S, Dazert E, Bock T, Song S, Buechel D, Morini MF, Hergovich A, Matthias P, Lim DS, Terracciano LM, Heim MH, Hall MN, Christofori G. Tang F, et al. Among authors: wyss cb. Nat Commun. 2019 Dec 17;10(1):5755. doi: 10.1038/s41467-019-13591-7. Nat Commun. 2019. PMID: 31848340 Free PMC article.