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Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.
Padilla AM, Wang W, Akama T, Carter DS, Easom E, Freund Y, Halladay JS, Liu Y, Hamer SA, Hodo CL, Wilkerson GK, Orr D, White B, George A, Shen H, Jin Y, Wang MZ, Tse S, Jacobs RT, Tarleton RL. Padilla AM, et al. Among authors: wang w, wang mz. Nat Microbiol. 2022 Oct;7(10):1536-1546. doi: 10.1038/s41564-022-01211-y. Epub 2022 Sep 5. Nat Microbiol. 2022. PMID: 36065062 Free PMC article.
Development of novel drugs for human African trypanosomiasis.
Brun R, Don R, Jacobs RT, Wang MZ, Barrett MP. Brun R, et al. Among authors: wang mz. Future Microbiol. 2011 Jun;6(6):677-91. doi: 10.2217/fmb.11.44. Future Microbiol. 2011. PMID: 21707314 Free article. Review.
Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway.
Feng M, Jin Y, Yang S, Joachim AM, Ning Y, Mori-Quiroz LM, Fromm J, Perera C, Zhang K, Werbovetz KA, Wang MZ. Feng M, et al. Among authors: wang mz. Int J Parasitol Drugs Drug Resist. 2022 Dec;20:27-42. doi: 10.1016/j.ijpddr.2022.07.003. Epub 2022 Aug 15. Int J Parasitol Drugs Drug Resist. 2022. PMID: 35994895 Free PMC article.
Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.
Thuita JK, Wolf KK, Murilla GA, Bridges AS, Boykin DW, Mutuku JN, Liu Q, Jones SK, Gem CO, Ching S, Tidwell RR, Wang MZ, Paine MF, Brun R. Thuita JK, et al. Among authors: wang mz. PLoS Negl Trop Dis. 2015 Feb 5;9(2):e0003409. doi: 10.1371/journal.pntd.0003409. eCollection 2015 Feb. PLoS Negl Trop Dis. 2015. PMID: 25654243 Free PMC article.
Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, Boykin DW, Wang MZ, Werbovetz KA. Zhu X, et al. Among authors: wang mz. Antimicrob Agents Chemother. 2012 Jul;56(7):3690-9. doi: 10.1128/AAC.06404-11. Epub 2012 Apr 16. Antimicrob Agents Chemother. 2012. PMID: 22508306 Free PMC article.
714 results