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Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G. De Rossi P, et al. Among authors: thinakaran g. Brain Pathol. 2019 Jul;29(4):485-501. doi: 10.1111/bpa.12687. Epub 2018 Dec 27. Brain Pathol. 2019. PMID: 30506549 Free PMC article.
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, Krause SV, Freedman DJ, Bindokas VP, Kasthuri N, Nicholson DA, Contractor A, Thinakaran G. De Rossi P, et al. Among authors: thinakaran g. Cell Rep. 2020 Mar 10;30(10):3520-3535.e7. doi: 10.1016/j.celrep.2020.02.026. Cell Rep. 2020. PMID: 32160554 Free PMC article.
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. Rynearson KD, et al. Among authors: thinakaran g. J Exp Med. 2021 Apr 5;218(4):e20202560. doi: 10.1084/jem.20202560. J Exp Med. 2021. PMID: 33651103 Free PMC article.
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia.
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, Rangaraju S. Sudwarts A, et al. Among authors: thinakaran g. Mol Neurodegener. 2022 May 7;17(1):33. doi: 10.1186/s13024-022-00535-x. Mol Neurodegener. 2022. PMID: 35526014 Free PMC article.
A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.
Udayar V, Buggia-Prévot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J; AESG; Simons M, Ries J, Puthenveedu MA, Hardy J, Thinakaran G, Rajendran L. Udayar V, et al. Among authors: thinakaran g. Cell Rep. 2013 Dec 26;5(6):1536-51. doi: 10.1016/j.celrep.2013.12.005. Cell Rep. 2013. PMID: 24373285 Free PMC article.
Alzheimer's genes in microglia: a risk worth investigating.
Sudwarts A, Thinakaran G. Sudwarts A, et al. Among authors: thinakaran g. Mol Neurodegener. 2023 Nov 20;18(1):90. doi: 10.1186/s13024-023-00679-4. Mol Neurodegener. 2023. PMID: 37986179 Free PMC article. Review.
136 results