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BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia.
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, Rangaraju S. Sudwarts A, et al. Among authors: ponnusamy m. Mol Neurodegener. 2022 May 7;17(1):33. doi: 10.1186/s13024-022-00535-x. Mol Neurodegener. 2022. PMID: 35526014 Free PMC article.
Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G. De Rossi P, et al. Among authors: ponnusamy m. Brain Pathol. 2019 Jul;29(4):485-501. doi: 10.1111/bpa.12687. Epub 2018 Dec 27. Brain Pathol. 2019. PMID: 30506549 Free PMC article.
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. Rynearson KD, et al. Among authors: ponnusamy m. J Exp Med. 2021 Apr 5;218(4):e20202560. doi: 10.1084/jem.20202560. J Exp Med. 2021. PMID: 33651103 Free PMC article.
Alzheimer's disease risk allele of PICALM causes detrimental lipid droplets in microglia.
Duan J, Kozlova A, Zhang S, Sudwards A, Zhang H, Smirnou S, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Pang Z, Sanders A, Bellen H, Thinakaran G. Duan J, et al. Among authors: ponnusamy m. Res Sq [Preprint]. 2024 May 24:rs.3.rs-4407146. doi: 10.21203/rs.3.rs-4407146/v1. Res Sq. 2024. PMID: 38826437 Free PMC article. Preprint.
Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma.
Atri P, Shah A, Natarajan G, Rachagani S, Rauth S, Ganguly K, Carmicheal J, Ghersi D, Cox JL, Smith LM, Jain M, Kumar S, Ponnusamy MP, Seshacharyulu P, Batra SK. Atri P, et al. Among authors: ponnusamy mp. NPJ Precis Oncol. 2024 Mar 7;8(1):66. doi: 10.1038/s41698-024-00562-5. NPJ Precis Oncol. 2024. PMID: 38454151 Free PMC article.
Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis.
Parte S, Kaur AB, Nimmakayala RK, Ogunleye AO, Chirravuri R, Vengoji R, Leon F, Nallasamy P, Rauth S, Alsafwani ZW, Lele S, Cox JL, Bhat I, Singh S, Batra SK, Ponnusamy MP. Parte S, et al. Among authors: ponnusamy mp. Gastroenterology. 2024 May;166(5):842-858.e5. doi: 10.1053/j.gastro.2023.12.018. Epub 2023 Dec 27. Gastroenterology. 2024. PMID: 38154529
188 results