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Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL. Henry JR, et al. J Med Chem. 2015 May 28;58(10):4165-79. doi: 10.1021/acs.jmedchem.5b00067. Epub 2015 May 12. J Med Chem. 2015. PMID: 25965804
Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Peng SB, Henry JR, Kaufman MD, Lu WP, Smith BD, Vogeti S, Rutkoski TJ, Wise S, Chun L, Zhang Y, Van Horn RD, Yin T, Zhang X, Yadav V, Chen SH, Gong X, Ma X, Webster Y, Buchanan S, Mochalkin I, Huber L, Kays L, Donoho GP, Walgren J, McCann D, Patel P, Conti I, Plowman GD, Starling JJ, Flynn DL. Peng SB, et al. Cancer Cell. 2015 Sep 14;28(3):384-98. doi: 10.1016/j.ccell.2015.08.002. Epub 2015 Sep 3. Cancer Cell. 2015. PMID: 26343583 Free article.
Study protocol: optical coherence tomography angiography for the detection of neovascular age-related macular degeneration: a comprehensive multicentre diagnostic accuracy study in the UK-the ATHENA study.
Niestrata M, Deeks JJ, Takwoingi Y, Sivaprasad S, Patel PJ, Keane PA, Kernohan A, Vale L, Denniston AK, Gale R, Khan AR, McKinnon W, Agarwal R, de Salvo G, Minos E, Barbeiro P, Chakravarthy U, Waheed NK, Madhusudhan S, Peto T, Balaskas K. Niestrata M, et al. Among authors: patel pj. BMJ Open. 2024 May 31;14(5):e070857. doi: 10.1136/bmjopen-2022-070857. BMJ Open. 2024. PMID: 38821570 Free PMC article.
The UK clinical eye research strategy: refreshing research priorities for clinical eye research in the UK.
Bourne RRA, Moledina M, Azuara-Blanco A, Saleh GM, Self JE, Sivaprasad S, Sharma SM, Ross A, Gilbert RM, Abdalla Elsayed MEA, Moon WY, Doug M, Mulholland PJ, Day AC, Romano V, Hoad GV, Kara M, Murray A, Gow L, Ghanchi F, Patel PJ, Gale RP, Dinah C, Valentine K, Yelf C, Poustie V; NIHR Ophthalmology Specialty Group; Executive Group of UK Clinical Eye Research Strategy. Bourne RRA, et al. Among authors: patel pj. Eye (Lond). 2024 May 29. doi: 10.1038/s41433-024-03049-6. Online ahead of print. Eye (Lond). 2024. PMID: 38806699
Morning light treatment for inflammatory bowel disease: a clinical trial.
Cohen-Mekelburg S, Goldstein CA, Rizvydeen M, Fayyaz Z, Patel PJ, Berinstein JA, Bishu S, Cushing-Damm KC, Kim HM, Burgess HJ. Cohen-Mekelburg S, et al. Among authors: patel pj. BMC Gastroenterol. 2024 May 22;24(1):179. doi: 10.1186/s12876-024-03263-2. BMC Gastroenterol. 2024. PMID: 38778264 Free PMC article.
Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months.
Fu DJ, Bagga P, Naik G, Glinton S, Faes L, Liefers B, Lima R, Wignall G, Keane PA, Ioannidou E, Ribeiro Reis AP, McKeown A, Scheibler L, Patel PJ, Moghul I, Pontikos N, Balaskas K. Fu DJ, et al. Among authors: patel pj. JAMA Ophthalmol. 2024 May 9:e241269. doi: 10.1001/jamaophthalmol.2024.1269. Online ahead of print. JAMA Ophthalmol. 2024. PMID: 38722644 Free PMC article.
406 results