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Caspase-2 activation in the absence of PIDDosome formation.
Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A. Manzl C, et al. Among authors: villunger a. J Cell Biol. 2009 Apr 20;185(2):291-303. doi: 10.1083/jcb.200811105. Epub 2009 Apr 13. J Cell Biol. 2009. PMID: 19364921 Free PMC article.
The PIDDosome activates p53 in response to supernumerary centrosomes.
Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A. Fava LL, et al. Among authors: villunger a. Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116. Genes Dev. 2017. PMID: 28130345 Free PMC article.
BOK promotes chemical-induced hepatocarcinogenesis in mice.
Rabachini T, Fernandez-Marrero Y, Montani M, Loforese G, Sladky V, He Z, Bachmann D, Wicki S, Villunger A, Stroka D, Kaufmann T. Rabachini T, et al. Among authors: villunger a. Cell Death Differ. 2018 Mar;25(4):708-720. doi: 10.1038/s41418-017-0008-0. Epub 2017 Dec 11. Cell Death Differ. 2018. PMID: 29229991 Free PMC article.
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.
Sladky VC, Knapp K, Soratroi C, Heppke J, Eichin F, Rocamora-Reverte L, Szabo TG, Bongiovanni L, Westendorp B, Moreno E, van Liere EA, Bakker B, Spierings DCJ, Wardenaar R, Pereyra D, Starlinger P, Schultze S, Trauner M, Stojakovic T, Scharnagl H, Fava LL, Foijer F, de Bruin A, Villunger A. Sladky VC, et al. Among authors: villunger a. Dev Cell. 2020 Feb 10;52(3):335-349.e7. doi: 10.1016/j.devcel.2019.12.016. Epub 2020 Jan 23. Dev Cell. 2020. PMID: 31983631 Free article.
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.
Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G, Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A. Sladky VC, et al. Among authors: villunger a. EMBO Rep. 2020 Dec 3;21(12):e50893. doi: 10.15252/embr.202050893. Epub 2020 Nov 23. EMBO Rep. 2020. PMID: 33225610 Free PMC article.
Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability.
Sheikh TI, Vasli N, Pastore S, Kharizi K, Harripaul R, Fattahi Z, Pande S, Naeem F, Hussain A, Mir A, Islam O, Girisha KM, Irfan M, Ayub M, Schwarzer C, Najmabadi H, Shukla A, Sladky VC, Braun VZ, Garcia-Carpio I, Villunger A, Vincent JB. Sheikh TI, et al. Among authors: villunger a. Transl Psychiatry. 2021 Jan 5;11(1):1. doi: 10.1038/s41398-020-01158-w. Transl Psychiatry. 2021. PMID: 33414379 Free PMC article.
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