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Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent.
Holmes SE, Bachran C, Fuchs H, Weng A, Melzig MF, Flavell SU, Flavell DJ. Holmes SE, et al. Among authors: flavell su, flavell dj. Immunopharmacol Immunotoxicol. 2015 Feb;37(1):42-55. doi: 10.3109/08923973.2014.971964. Epub 2014 Oct 27. Immunopharmacol Immunotoxicol. 2015. PMID: 25347443
Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems.
Della Cristina P, Castagna M, Lombardi A, Barison E, Tagliabue G, Ceriotti A, Koutris I, Di Leandro L, Giansanti F, Vago R, Ippoliti R, Flavell SU, Flavell DJ, Colombatti M, Fabbrini MS. Della Cristina P, et al. Among authors: flavell su, flavell dj. Microb Cell Fact. 2015 Feb 13;14:19. doi: 10.1186/s12934-015-0202-z. Microb Cell Fact. 2015. PMID: 25889802 Free PMC article.
Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera.
Errico Provenzano A, Posteri R, Giansanti F, Angelucci F, Flavell SU, Flavell DJ, Fabbrini MS, Porro D, Ippoliti R, Ceriotti A, Branduardi P, Vago R. Errico Provenzano A, et al. Among authors: flavell dj. Microb Cell Fact. 2016 Nov 14;15(1):194. doi: 10.1186/s12934-016-0589-1. Microb Cell Fact. 2016. PMID: 27842546 Free PMC article.
Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells.
Smith WS, Baker EJ, Holmes SE, Koster G, Hunt AN, Johnston DA, Flavell SU, Flavell DJ. Smith WS, et al. Among authors: flavell dj. Biochim Biophys Acta Biomembr. 2017 May;1859(5):993-1007. doi: 10.1016/j.bbamem.2017.02.013. Epub 2017 Feb 21. Biochim Biophys Acta Biomembr. 2017. PMID: 28235471 Free article.
60 results