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Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [11C]CHDI-00485180-R and [11C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin.
Delva A, Koole M, Serdons K, Bormans G, Liu L, Bard J, Khetarpal V, Dominguez C, Munoz-Sanjuan I, Wood A, Skinbjerg M, Wang Y, Vandenberghe W, Van Laere K. Delva A, et al. Among authors: skinbjerg m. Eur J Nucl Med Mol Imaging. 2022 Dec;50(1):48-60. doi: 10.1007/s00259-022-05945-z. Epub 2022 Aug 24. Eur J Nucl Med Mol Imaging. 2022. PMID: 36001116
Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington's disease.
Bertoglio D, Verhaeghe J, Miranda A, Wyffels L, Stroobants S, Mrzljak L, Khetarpal V, Skinbjerg M, Liu L, Dominguez C, Munoz-Sanjuan I, Bard J, Staelens S. Bertoglio D, et al. Among authors: skinbjerg m. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1166-1175. doi: 10.1007/s00259-021-05578-8. Epub 2021 Oct 15. Eur J Nucl Med Mol Imaging. 2022. PMID: 34651228 Free PMC article.
Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem.
Bertoglio D, Verhaeghe J, Wyffels L, Miranda A, Stroobants S, Mrzljak L, Dominguez C, Skinbjerg M, Bard J, Liu L, Munoz-Sanjuan I, Staelens S. Bertoglio D, et al. Among authors: skinbjerg m. J Nucl Med. 2022 Jun;63(6):942-947. doi: 10.2967/jnumed.121.262709. Epub 2021 Sep 16. J Nucl Med. 2022. PMID: 34531262 Free PMC article.
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease.
Bertoglio D, Bard J, Hessmann M, Liu L, Gärtner A, De Lombaerde S, Huscher B, Zajicek F, Miranda A, Peters F, Herrmann F, Schaertl S, Vasilkovska T, Brown CJ, Johnson PD, Prime ME, Mills MR, Van der Linden A, Mrzljak L, Khetarpal V, Wang Y, Marchionini DM, Skinbjerg M, Verhaeghe J, Dominguez C, Staelens S, Munoz-Sanjuan I. Bertoglio D, et al. Among authors: skinbjerg m. Sci Transl Med. 2022 Feb 2;14(630):eabm3682. doi: 10.1126/scitranslmed.abm3682. Epub 2022 Feb 2. Sci Transl Med. 2022. PMID: 35108063
Validation and noninvasive kinetic modeling of [11C]UCB-J PET imaging in mice.
Bertoglio D, Verhaeghe J, Miranda A, Kertesz I, Cybulska K, Korat Š, Wyffels L, Stroobants S, Mrzljak L, Dominguez C, Liu L, Skinbjerg M, Munoz-Sanjuan I, Staelens S. Bertoglio D, et al. Among authors: skinbjerg m. J Cereb Blood Flow Metab. 2020 Jun;40(6):1351-1362. doi: 10.1177/0271678X19864081. Epub 2019 Jul 15. J Cereb Blood Flow Metab. 2020. PMID: 31307287 Free PMC article.
Elevated Type 1 Metabotropic Glutamate Receptor Availability in a Mouse Model of Huntington's Disease: a Longitudinal PET Study.
Bertoglio D, Verhaeghe J, Korat Š, Miranda A, Cybulska K, Wyffels L, Stroobants S, Mrzljak L, Dominguez C, Skinbjerg M, Liu L, Munoz-Sanjuan I, Staelens S. Bertoglio D, et al. Among authors: skinbjerg m. Mol Neurobiol. 2020 Apr;57(4):2038-2047. doi: 10.1007/s12035-019-01866-5. Epub 2020 Jan 8. Mol Neurobiol. 2020. PMID: 31912442 Free PMC article.
19 results