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In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system.
Chu L, Terasaki M, Mattsson CL, Teinturier R, Charbord J, Dirice E, Liu KC, Miskelly MG, Zhou Q, Wierup N, Kulkarni RN, Andersson O. Chu L, et al. Among authors: kulkarni rn. Cell Chem Biol. 2022 Sep 15;29(9):1368-1380.e5. doi: 10.1016/j.chembiol.2022.08.001. Epub 2022 Aug 22. Cell Chem Biol. 2022. PMID: 35998625 Free PMC article.
GIP: no longer the neglected incretin twin?
Kulkarni RN. Kulkarni RN. Sci Transl Med. 2010 Sep 15;2(49):49ps47. doi: 10.1126/scitranslmed.3001027. Sci Transl Med. 2010. PMID: 20844284
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.
El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. El Ouaamari A, et al. Among authors: kulkarni rn. Cell Rep. 2013 Feb 21;3(2):401-10. doi: 10.1016/j.celrep.2013.01.007. Epub 2013 Jan 31. Cell Rep. 2013. PMID: 23375376 Free PMC article.
Soluble factors secreted by T cells promote β-cell proliferation.
Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Dirice E, et al. Among authors: kulkarni rn. Diabetes. 2014 Jan;63(1):188-202. doi: 10.2337/db13-0204. Epub 2013 Oct 2. Diabetes. 2014. PMID: 24089508 Free PMC article.
Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.
El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG 2nd, Smith RD, Qian WJ, Kulkarni RN. El Ouaamari A, et al. Among authors: kulkarni rn. J Proteome Res. 2015 Aug 7;14(8):3111-3122. doi: 10.1021/acs.jproteome.5b00587. Epub 2015 Jul 30. J Proteome Res. 2015. PMID: 26151086 Free PMC article.
Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.
Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Bhatt S, et al. Among authors: kulkarni rn. Cell Metab. 2015 Aug 4;22(2):239-52. doi: 10.1016/j.cmet.2015.07.015. Cell Metab. 2015. PMID: 26244933 Free PMC article.
295 results