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Multi-steroid profiling by UHPLC-MS/MS with post-column infusion of ammonium fluoride.
Schiffer L, Shaheen F, Gilligan LC, Storbeck KH, Hawley JM, Keevil BG, Arlt W, Taylor AE. Schiffer L, et al. Among authors: arlt w. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Oct 15;1209:123413. doi: 10.1016/j.jchromb.2022.123413. Epub 2022 Aug 9. J Chromatogr B Analyt Technol Biomed Life Sci. 2022. PMID: 35988498 Free article.
Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).
Krone N, Hughes BA, Lavery GG, Stewart PM, Arlt W, Shackleton CH. Krone N, et al. Among authors: arlt w. J Steroid Biochem Mol Biol. 2010 Aug;121(3-5):496-504. doi: 10.1016/j.jsbmb.2010.04.010. Epub 2010 Apr 22. J Steroid Biochem Mol Biol. 2010. PMID: 20417277 Free PMC article. Review.
Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors.
Arlt W, Biehl M, Taylor AE, Hahner S, Libé R, Hughes BA, Schneider P, Smith DJ, Stiekema H, Krone N, Porfiri E, Opocher G, Bertherat J, Mantero F, Allolio B, Terzolo M, Nightingale P, Shackleton CH, Bertagna X, Fassnacht M, Stewart PM. Arlt W, et al. J Clin Endocrinol Metab. 2011 Dec;96(12):3775-84. doi: 10.1210/jc.2011-1565. Epub 2011 Sep 14. J Clin Endocrinol Metab. 2011. PMID: 21917861 Free PMC article.
Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.
Chortis V, Taylor AE, Schneider P, Tomlinson JW, Hughes BA, O'Neil DM, Libé R, Allolio B, Bertagna X, Bertherat J, Beuschlein F, Fassnacht M, Karavitaki N, Mannelli M, Mantero F, Opocher G, Porfiri E, Quinkler M, Sherlock M, Terzolo M, Nightingale P, Shackleton CH, Stewart PM, Hahner S, Arlt W. Chortis V, et al. Among authors: arlt w. J Clin Endocrinol Metab. 2013 Jan;98(1):161-71. doi: 10.1210/jc.2012-2851. Epub 2012 Nov 16. J Clin Endocrinol Metab. 2013. PMID: 23162091 Free article. Clinical Trial.
Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.
Mahata B, Zhang X, Kolodziejczyk AA, Proserpio V, Haim-Vilmovsky L, Taylor AE, Hebenstreit D, Dingler FA, Moignard V, Göttgens B, Arlt W, McKenzie AN, Teichmann SA. Mahata B, et al. Among authors: arlt w. Cell Rep. 2014 May 22;7(4):1130-42. doi: 10.1016/j.celrep.2014.04.011. Epub 2014 May 10. Cell Rep. 2014. PMID: 24813893 Free PMC article.
379 results