Yang L - Search Results

1

Recent advances in β-lactamase inhibitor chemotypes and inhibition modes.

Li R, Chen X, Zhou C, Dai QQ, Yang L. Li R, et al. Among authors: yang l. Eur J Med Chem. 2022 Nov 15;242:114677. doi: 10.1016/j.ejmech.2022.114677. Epub 2022 Aug 13. Eur J Med Chem. 2022. PMID: 35988449 Review.

2

Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met.

Xie QQ, Zhong L, Pan YL, Wang XY, Zhou JP, Di-Wu L, Huang Q, Wang YL, Yang LL, Xie HZ, Yang SY. Xie QQ, et al. Among authors: yang sy, yang ll. Eur J Med Chem. 2011 Sep;46(9):3675-80. doi: 10.1016/j.ejmech.2011.05.031. Epub 2011 May 25. Eur J Med Chem. 2011. PMID: 21641696

3

Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.

Li WW, Wang XY, Zheng RL, Yan HX, Cao ZX, Zhong L, Wang ZR, Ji P, Yang LL, Wang LJ, Xu Y, Liu JJ, Yang J, Zhang CH, Ma S, Feng S, Sun QZ, Wei YQ, Yang SY. Li WW, et al. Among authors: yang sy, yang ll, yang j. J Med Chem. 2012 Apr 26;55(8):3852-66. doi: 10.1021/jm300042x. Epub 2012 Apr 6. J Med Chem. 2012. PMID: 22452518

4

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

Yang LL, Li GB, Yan HX, Sun QZ, Ma S, Ji P, Wang ZR, Feng S, Zou J, Yang SY. Yang LL, et al. Eur J Med Chem. 2012 Oct;56:30-8. doi: 10.1016/j.ejmech.2012.08.007. Epub 2012 Aug 14. Eur J Med Chem. 2012. PMID: 22944772

5

Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.

Yang LL, Li GB, Ma S, Zou C, Zhou S, Sun QZ, Cheng C, Chen X, Wang LJ, Feng S, Li LL, Yang SY. Yang LL, et al. J Med Chem. 2013 Feb 28;56(4):1641-55. doi: 10.1021/jm301537p. Epub 2013 Feb 19. J Med Chem. 2013. PMID: 23362959

6

LEADOPT: an automatic tool for structure-based lead optimization, and its application in structural optimizations of VEGFR2 and SYK inhibitors.

Li GB, Ji S, Yang LL, Zhang RJ, Chen K, Zhong L, Ma S, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. Eur J Med Chem. 2015 Mar 26;93:523-38. doi: 10.1016/j.ejmech.2015.02.019. Epub 2015 Feb 14. Eur J Med Chem. 2015. PMID: 25743214

7

Drug Discovery against Psoriasis: Identification of a New Potent FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor, 1-(4-((1H-Pyrazolo[3,4-d]pyrimidin-4-yl)oxy)-3-fluorophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea, That Showed Potent Activity in a Psoriatic Animal Model.

Li GB, Ma S, Yang LL, Ji S, Fang Z, Zhang G, Wang LJ, Zhong JM, Xiong Y, Wang JH, Huang SZ, Li LL, Xiang R, Niu D, Chen YC, Yang SY. Li GB, et al. J Med Chem. 2016 Sep 22;59(18):8293-305. doi: 10.1021/acs.jmedchem.6b00604. Epub 2016 Sep 2. J Med Chem. 2016. PMID: 27535613

8

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.

Yang L, Ma X, Yuan C, He Y, Li L, Fang S, Xia W, He T, Qian S, Xu Z, Li G, Wang Z. Yang L, et al. Eur J Med Chem. 2017 Jul 7;134:230-241. doi: 10.1016/j.ejmech.2017.04.010. Epub 2017 Apr 12. Eur J Med Chem. 2017. PMID: 28415012

9

Virtual target screening reveals rosmarinic acid and salvianolic acid A inhibiting metallo- and serine-β-lactamases.

Yu ZJ, Liu S, Zhou S, Li H, Yang F, Yang LL, Wu Y, Guo L, Li GB. Yu ZJ, et al. Among authors: yang f, yang ll. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1037-1042. doi: 10.1016/j.bmcl.2018.02.025. Epub 2018 Feb 14. Bioorg Med Chem Lett. 2018. PMID: 29477271

10

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.

Yang LL, Wang HL, Zhong L, Yuan C, Liu SY, Yu ZJ, Liu S, Yan YH, Wu C, Wang Y, Wang Z, Yu Y, Chen Q, Li GB. Yang LL, et al. Eur J Med Chem. 2018 Jul 15;155:806-823. doi: 10.1016/j.ejmech.2018.06.041. Epub 2018 Jun 19. Eur J Med Chem. 2018. PMID: 29957526

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