Hargrove AE - Search Results

1

Multiassay Profiling of a Focused Small Molecule Library Reveals Predictive Bidirectional Modulation of the lncRNA MALAT1 Triplex Stability In Vitro.

Zafferani M, Martyr JG, Muralidharan D, Montalvan NI, Cai Z, Hargrove AE. Zafferani M, et al. Among authors: hargrove ae. ACS Chem Biol. 2022 Sep 16;17(9):2437-2447. doi: 10.1021/acschembio.2c00124. Epub 2022 Aug 19. ACS Chem Biol. 2022. PMID: 35984959 Free PMC article.

2

Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.

McFadden EJ, Hargrove AE. McFadden EJ, et al. Among authors: hargrove ae. Biochemistry. 2016 Mar 22;55(11):1615-30. doi: 10.1021/acs.biochem.5b01141. Epub 2016 Feb 24. Biochemistry. 2016. PMID: 26859437 Free PMC article. Review.

3

Small Molecule-Based Pattern Recognition To Classify RNA Structure.

Eubanks CS, Forte JE, Kapral GJ, Hargrove AE. Eubanks CS, et al. Among authors: hargrove ae. J Am Chem Soc. 2017 Jan 11;139(1):409-416. doi: 10.1021/jacs.6b11087. Epub 2016 Dec 22. J Am Chem Soc. 2017. PMID: 28004925 Free PMC article.

4

Sensing the impact of environment on small molecule differentiation of RNA sequences.

Eubanks CS, Hargrove AE. Eubanks CS, et al. Among authors: hargrove ae. Chem Commun (Camb). 2017 Dec 14;53(100):13363-13366. doi: 10.1039/c7cc07157d. Chem Commun (Camb). 2017. PMID: 29199743

5

Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.

Donlic A, Morgan BS, Xu JL, Liu A, Roble C Jr, Hargrove AE. Donlic A, et al. Among authors: hargrove ae. Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13242-13247. doi: 10.1002/anie.201808823. Epub 2018 Sep 10. Angew Chem Int Ed Engl. 2018. PMID: 30134013 Free PMC article.

6

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA.

Patwardhan NN, Cai Z, Newson CN, Hargrove AE. Patwardhan NN, et al. Among authors: hargrove ae. Org Biomol Chem. 2019 Feb 13;17(7):1778-1786. doi: 10.1039/c8ob02467g. Org Biomol Chem. 2019. PMID: 30468226 Free PMC article.

7

Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions.

Umuhire Juru A, Patwardhan NN, Hargrove AE. Umuhire Juru A, et al. Among authors: hargrove ae. ACS Chem Biol. 2019 May 17;14(5):824-838. doi: 10.1021/acschembio.8b00945. Epub 2019 May 1. ACS Chem Biol. 2019. PMID: 31042354 Free PMC article. Review.

8

R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.

Morgan BS, Sanaba BG, Donlic A, Karloff DB, Forte JE, Zhang Y, Hargrove AE. Morgan BS, et al. Among authors: hargrove ae. ACS Chem Biol. 2019 Dec 20;14(12):2691-2700. doi: 10.1021/acschembio.9b00631. Epub 2019 Oct 29. ACS Chem Biol. 2019. PMID: 31589399 Free PMC article.

9

Driving factors in amiloride recognition of HIV RNA targets.

Patwardhan NN, Cai Z, Umuhire Juru A, Hargrove AE. Patwardhan NN, et al. Among authors: hargrove ae. Org Biomol Chem. 2019 Oct 30;17(42):9313-9320. doi: 10.1039/c9ob01702j. Org Biomol Chem. 2019. PMID: 31612165 Free PMC article.

10

Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.

Ganser LR, Kelly ML, Patwardhan NN, Hargrove AE, Al-Hashimi HM. Ganser LR, et al. Among authors: hargrove ae. J Mol Biol. 2020 Feb 14;432(4):1297-1304. doi: 10.1016/j.jmb.2019.12.009. Epub 2019 Dec 18. J Mol Biol. 2020. PMID: 31863746 Free PMC article.

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