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Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo.
Abram M, Jakubiec M, Reeb K, Cheng MH, Gedschold R, Rapacz A, Mogilski S, Socała K, Nieoczym D, Szafarz M, Latacz G, Szulczyk B, Kalinowska-Tłuścik J, Gawel K, Esguerra CV, Wyska E, Müller CE, Bahar I, Fontana ACK, Wlaź P, Kamiński RM, Kamiński K. Abram M, et al. Among authors: szafarz m. J Med Chem. 2022 Sep 8;65(17):11703-11725. doi: 10.1021/acs.jmedchem.2c00534. Epub 2022 Aug 19. J Med Chem. 2022. PMID: 35984707 Free PMC article.
Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method.
Szafarz M, Wencel A, Pociecha K, Fedak FA, Wlaź P, Wyska E. Szafarz M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):185-196. doi: 10.1007/s00210-017-1448-2. Epub 2017 Dec 12. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29230490 Free PMC article.
KSK19 - Novel histamine H3 receptor ligand reduces body weight in diet induced obese mice.
Kotańska M, Mika K, Reguła K, Szczepańska K, Szafarz M, Bednarski M, Olejarz-Maciej A, Nowak K, Latacz G, Mogilski S, Kuder KJ, Kieć-Kononowicz K, Sapa J. Kotańska M, et al. Among authors: szafarz m. Biochem Pharmacol. 2019 Oct;168:193-203. doi: 10.1016/j.bcp.2019.07.006. Epub 2019 Jul 8. Biochem Pharmacol. 2019. PMID: 31295465
Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands.
Szczepańska K, Karcz T, Siwek A, Kuder KJ, Latacz G, Bednarski M, Szafarz M, Hagenow S, Lubelska A, Olejarz-Maciej A, Sobolewski M, Mika K, Kotańska M, Stark H, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: szafarz m. Bioorg Chem. 2019 Oct;91:103071. doi: 10.1016/j.bioorg.2019.103071. Epub 2019 Jun 20. Bioorg Chem. 2019. PMID: 31362197
42 results