Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

111 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.
Van Trimpont M, Schalk AM, De Visser Y, Nguyen HA, Reunes L, Vandemeulebroecke K, Peeters E, Su Y, Lee H, Lorenzi PL, Chan WK, Mondelaers V, De Moerloose B, Lammens T, Goossens S, Van Vlierberghe P, Lavie A. Van Trimpont M, et al. Among authors: lorenzi pl. Haematologica. 2023 Feb 1;108(2):409-419. doi: 10.3324/haematol.2022.281390. Haematologica. 2023. PMID: 35979719 Free PMC article.
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Chan WK, Horvath TD, Tan L, Link T, Harutyunyan KG, Pontikos MA, Anishkin A, Du D, Martin LA, Yin E, Rempe SB, Sukharev S, Konopleva M, Weinstein JN, Lorenzi PL. Chan WK, et al. Among authors: lorenzi pl. Mol Cancer Ther. 2019 Sep;18(9):1587-1592. doi: 10.1158/1535-7163.MCT-18-1329. Epub 2019 Jun 17. Mol Cancer Ther. 2019. PMID: 31209181 Free PMC article.
Mechanism of Catalysis by l-Asparaginase.
Lubkowski J, Vanegas J, Chan WK, Lorenzi PL, Weinstein JN, Sukharev S, Fushman D, Rempe S, Anishkin A, Wlodawer A. Lubkowski J, et al. Among authors: lorenzi pl. Biochemistry. 2020 May 26;59(20):1927-1945. doi: 10.1021/acs.biochem.0c00116. Epub 2020 May 11. Biochemistry. 2020. PMID: 32364696
Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
Grima-Reyes M, Vandenberghe A, Nemazanyy I, Meola P, Paul R, Reverso-Meinietti J, Martinez-Turtos A, Nottet N, Chan WK, Lorenzi PL, Marchetti S, Ricci JE, Chiche J. Grima-Reyes M, et al. Among authors: lorenzi pl. Sci Adv. 2022 Jul 8;8(27):eabn6491. doi: 10.1126/sciadv.abn6491. Epub 2022 Jul 6. Sci Adv. 2022. PMID: 35857457 Free PMC article.
Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer.
Horvath TD, Chan WK, Pontikos MA, Martin LA, Du D, Tan L, Konopleva M, Weinstein JN, Lorenzi PL. Horvath TD, et al. Among authors: lorenzi pl. Metabolites. 2019 Jan 9;9(1):10. doi: 10.3390/metabo9010010. Metabolites. 2019. PMID: 30634463 Free PMC article.
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du D, Yang JJ, Hoff FW, Kaminski M, Tomczak K, Eric Davis R, Herranz D, Ferrando A, Jabbour EJ, Emilia Di Francesco M, Teachey DT, Horton TM, Kornblau S, Rezvani K, Sauvageau G, Gagea M, Andreeff M, Takahashi K, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva M. Baran N, et al. Among authors: lorenzi pl. Nat Commun. 2022 May 19;13(1):2801. doi: 10.1038/s41467-022-30396-3. Nat Commun. 2022. PMID: 35589701 Free PMC article.
111 results