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Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
Iijima D, Sugama H, Awai N, Takahashi Y, Togashi Y, Takebe T, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T. Iijima D, et al. Among authors: togashi y. ACS Med Chem Lett. 2022 Aug 1;13(8):1351-1357. doi: 10.1021/acsmedchemlett.2c00280. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978678 Free PMC article.
Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
Iijima D, Sugama H, Takahashi Y, Hirai M, Togashi Y, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T. Iijima D, et al. Among authors: togashi y. J Med Chem. 2022 Aug 25;65(16):10882-10897. doi: 10.1021/acs.jmedchem.2c00834. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35939295
Three-year outcomes of preoperative chemoradiotherapy plus nivolumab in microsatellite stable and microsatellite instability-high locally advanced rectal cancer.
Tsukada Y, Bando H, Inamori K, Wakabayashi M, Togashi Y, Koyama S, Kotani D, Yuki S, Komatsu Y, Homma S, Taketomi A, Uemura M, Kato T, Fukui M, Nakamura N, Kojima M, Kawachi H, Kirsch R, Yoshida T, Sato A, Nishikawa H, Ito M, Yoshino T. Tsukada Y, et al. Among authors: togashi y. Br J Cancer. 2024 Jun 4. doi: 10.1038/s41416-024-02730-7. Online ahead of print. Br J Cancer. 2024. PMID: 38834744
Early gastric cancer with RhoGAP fusion is linked to frequent nodal metastasis and a part of microtubular-mucocellular histology.
Noda H, Sakata S, Baba S, Togashi Y, Nakano K, Hirasawa T, Nakayama I, Hata C, Takamatsu M, Sugawara E, Yamamoto N, Fujisaki J, Nunobe S, Iwakiri K, Takeuchi K, Kawachi H. Noda H, et al. Among authors: togashi y. Gastric Cancer. 2024 May 16. doi: 10.1007/s10120-024-01507-4. Online ahead of print. Gastric Cancer. 2024. PMID: 38755445
CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling.
Naoi Y, Morinaga T, Nagasaki J, Ariyasu R, Ueda Y, Yamashita K, Zhou W, Kawashima S, Kawase K, Honobe-Tabuchi A, Ohnuma T, Kawamura T, Umeda Y, Kawahara Y, Nakamura Y, Kiniwa Y, Yamasaki O, Fukushima S, Kawazu M, Suzuki Y, Nishikawa H, Hanazawa T, Ando M, Inozume T, Togashi Y. Naoi Y, et al. Among authors: togashi y. Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-0453. Online ahead of print. Cancer Res. 2024. PMID: 38635899
Novel THBS1::IGF1R fusion in myopericytic tumour.
Kato K, Yamashita K, Dobashi A, Togashi Y, Baba S, Ae K, Matsumoto S, Takeuchi K. Kato K, et al. Among authors: togashi y. Histopathology. 2024 Apr 4. doi: 10.1111/his.15186. Online ahead of print. Histopathology. 2024. PMID: 38576274 No abstract available.
Soluble immune checkpoint factors reflect exhaustion of antitumor immunity and response to PD-1 blockade.
Hayashi H, Chamoto K, Hatae R, Kurosaki T, Togashi Y, Fukuoka K, Goto M, Chiba Y, Tomida S, Ota T, Haratani K, Takahama T, Tanizaki J, Yoshida T, Iwasa T, Tanaka K, Takeda M, Hirano T, Yoshida H, Ozasa H, Sakamori Y, Sakai K, Higuchi K, Uga H, Suminaka C, Hirai T, Nishio K, Nakagawa K, Honjo T. Hayashi H, et al. Among authors: togashi y. J Clin Invest. 2024 Apr 1;134(7):e168318. doi: 10.1172/JCI168318. J Clin Invest. 2024. PMID: 38557498 Free PMC article.
Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer's disease and mild cognitive impairment.
Yamashiro K, Takabayashi K, Kamagata K, Nishimoto Y, Togashi Y, Yamauchi Y, Ogaki K, Li Y, Hatano T, Motoi Y, Suzuki M, Miyakawa K, Ishikawa D, Aoki S, Urabe T, Hattori N. Yamashiro K, et al. Among authors: togashi y. Neurobiol Dis. 2024 Apr;193:106464. doi: 10.1016/j.nbd.2024.106464. Epub 2024 Mar 5. Neurobiol Dis. 2024. PMID: 38452948 Free article.
373 results