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CaMKII as a Therapeutic Target in Cardiovascular Disease.
Reyes Gaido OE, Nkashama LJ, Schole KL, Wang Q, Umapathi P, Mesubi OO, Konstantinidis K, Luczak ED, Anderson ME. Reyes Gaido OE, et al. Among authors: anderson me. Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:249-272. doi: 10.1146/annurev-pharmtox-051421-111814. Epub 2022 Aug 16. Annu Rev Pharmacol Toxicol. 2023. PMID: 35973713 Free PMC article. Review.
CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations.
Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME. Koval OM, et al. Among authors: anderson me. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4996-5000. doi: 10.1073/pnas.0913760107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194790 Free PMC article.
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Swaminathan PD, et al. Among authors: anderson me. J Clin Invest. 2011 Aug;121(8):3277-88. doi: 10.1172/JCI57833. Epub 2011 Jul 25. J Clin Invest. 2011. PMID: 21785215 Free PMC article.
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME. He BJ, et al. Among authors: anderson me. Nat Med. 2011 Nov 13;17(12):1610-8. doi: 10.1038/nm.2506. Nat Med. 2011. PMID: 22081025 Free PMC article.
CaMKII determines mitochondrial stress responses in heart.
Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME. Joiner ML, et al. Among authors: anderson me. Nature. 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. Epub 2012 Oct 10. Nature. 2012. PMID: 23051746 Free PMC article.
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.
Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Maier LS, Efimov IR, Hund TJ, Anderson ME. Luo M, et al. Among authors: anderson me. J Clin Invest. 2013 Mar;123(3):1262-74. doi: 10.1172/JCI65268. Epub 2013 Feb 15. J Clin Invest. 2013. PMID: 23426181 Free PMC article.
CaMKII is essential for the proasthmatic effects of oxidation.
Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME. Sanders PN, et al. Among authors: anderson me. Sci Transl Med. 2013 Jul 24;5(195):195ra97. doi: 10.1126/scitranslmed.3006135. Sci Transl Med. 2013. PMID: 23884469 Free PMC article.
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.
Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Purohit A, et al. Among authors: anderson me. Circulation. 2013 Oct 15;128(16):1748-57. doi: 10.1161/CIRCULATIONAHA.113.003313. Epub 2013 Sep 12. Circulation. 2013. PMID: 24030498 Free PMC article.
679 results