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Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection.
Chen D, Tan X, Chen W, Liu Y, Li C, Wu J, Zheng J, Shen HC, Zhang M, Wu W, Wang L, Xiong J, Dai J, Sun K, Zhang JD, Xiang K, Li B, Ni X, Zhu Q, Gao L, Wang L, Feng S. Chen D, et al. Among authors: zhang m, zhang jd. J Med Chem. 2022 Aug 25;65(16):10938-10955. doi: 10.1021/acs.jmedchem.1c02215. Epub 2022 Aug 16. J Med Chem. 2022. PMID: 35973101
A novel orally available small molecule that inhibits hepatitis B virus expression.
Mueller H, Wildum S, Luangsay S, Walther J, Lopez A, Tropberger P, Ottaviani G, Lu W, Parrott NJ, Zhang JD, Schmucki R, Racek T, Hoflack JC, Kueng E, Point F, Zhou X, Steiner G, Lütgehetmann M, Rapp G, Volz T, Dandri M, Yang S, Young JAT, Javanbakht H. Mueller H, et al. Among authors: zhang jd. J Hepatol. 2018 Mar;68(3):412-420. doi: 10.1016/j.jhep.2017.10.014. Epub 2017 Oct 25. J Hepatol. 2018. PMID: 29079285 Free article.
Causal inference in drug discovery and development.
Michoel T, Zhang JD. Michoel T, et al. Among authors: zhang jd. Drug Discov Today. 2023 Oct;28(10):103737. doi: 10.1016/j.drudis.2023.103737. Epub 2023 Aug 15. Drug Discov Today. 2023. PMID: 37591410 Free article. Review.
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment.
Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S. Jaklin M, et al. Among authors: zhang jd. Toxicol Sci. 2022 Jun 28;188(1):17-33. doi: 10.1093/toxsci/kfac046. Toxicol Sci. 2022. PMID: 35485993 Free PMC article.
Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening.
Gutbier S, Wanke F, Dahm N, Rümmelin A, Zimmermann S, Christensen K, Köchl F, Rautanen A, Hatje K, Geering B, Zhang JD, Britschgi M, Cowley SA, Patsch C. Gutbier S, et al. Among authors: zhang jd. Int J Mol Sci. 2020 Jul 7;21(13):4808. doi: 10.3390/ijms21134808. Int J Mol Sci. 2020. PMID: 32645954 Free PMC article.
Ten simple rules for doing a postdoc in pharma.
Zhang JD. Zhang JD. PLoS Comput Biol. 2021 Jun 3;17(6):e1008989. doi: 10.1371/journal.pcbi.1008989. eCollection 2021 Jun. PLoS Comput Biol. 2021. PMID: 34081699 Free PMC article.
Multiscale modelling of drug mechanism and safety.
Zhang JD, Sach-Peltason L, Kramer C, Wang K, Ebeling M. Zhang JD, et al. Drug Discov Today. 2020 Mar;25(3):519-534. doi: 10.1016/j.drudis.2019.12.009. Epub 2019 Dec 30. Drug Discov Today. 2020. PMID: 31899257 Free article. Review.
Tissue heterogeneity is prevalent in gene expression studies.
Sturm G, List M, Zhang JD. Sturm G, et al. Among authors: zhang jd. NAR Genom Bioinform. 2021 Sep 3;3(3):lqab077. doi: 10.1093/nargab/lqab077. eCollection 2021 Sep. NAR Genom Bioinform. 2021. PMID: 34514392 Free PMC article.
442 results