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TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate.
Hesterberg RS, Liu M, Elmarsafawi AG, Koomen JM, Welsh EA, Hesterberg SG, Ranatunga S, Yang C, Li W, Lawrence HR, Rodriguez PC, Berglund AE, Cleveland JL. Hesterberg RS, et al. Among authors: lawrence hr. Cancer Immunol Res. 2022 Oct 4;10(10):1263-1279. doi: 10.1158/2326-6066.CIR-21-0813. Cancer Immunol Res. 2022. PMID: 35969234 Free PMC article.
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, Yoder JA, Rajadhyaksha AM, Schönbrunn E, Lawrence HR, Lawrence NJ, Epling-Burnette PK. Akuffo AA, et al. Among authors: lawrence nj, lawrence hr. J Biol Chem. 2018 Apr 20;293(16):6187-6200. doi: 10.1074/jbc.M117.816868. Epub 2018 Feb 15. J Biol Chem. 2018. PMID: 29449372 Free PMC article.
Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets.
Sumi NJ, Ctortecka C, Hu Q, Bryant AT, Fang B, Remsing Rix LL, Ayaz M, Kinose F, Welsh EA, Eschrich SA, Lawrence HR, Koomen JM, Haura EB, Rix U. Sumi NJ, et al. Among authors: lawrence hr. Cell Chem Biol. 2019 Sep 19;26(9):1240-1252.e11. doi: 10.1016/j.chembiol.2019.06.003. Epub 2019 Jun 27. Cell Chem Biol. 2019. PMID: 31257184 Free PMC article.
Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity.
Walton K, Fernandez MR, Sagatys EM, Reff J, Kim J, Lee MC, Kiluk JV, Hui JYC, McKenna D Jr, Hupp M, Forster C, Linden MA, Lawrence NJ, Lawrence HR, Pidala J, Pavletic SZ, Blazar BR, Sebti SM, Cleveland JL, Anasetti C, Betts BC. Walton K, et al. Among authors: lawrence nj, lawrence hr. JCI Insight. 2020 May 7;5(9):e136437. doi: 10.1172/jci.insight.136437. JCI Insight. 2020. PMID: 32255769 Free PMC article.
Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes.
Hesterberg RS, Beatty MS, Han Y, Fernandez MR, Akuffo AA, Goodheart WE, Yang C, Chang S, Colin CM, Alontaga AY, McDaniel JM, Mailloux AW, Billington JMR, Yue L, Russell S, Gillies RJ, Yun SY, Ayaz M, Lawrence NJ, Lawrence HR, Yu XZ, Fu J, Darville LN, Koomen JM, Ren X, Messina J, Jiang K, Garrett TJ, Rajadhyaksha AM, Cleveland JL, Epling-Burnette PK. Hesterberg RS, et al. Among authors: lawrence nj, lawrence hr. Blood. 2020 Aug 13;136(7):857-870. doi: 10.1182/blood.2019003257. Blood. 2020. PMID: 32403132 Free PMC article.
93 results