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BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein.
Manangeeswaran M, Ireland DDC, Thacker SG, Lee HN, Kelley-Baker L, Lewkowicz AP, Rothlauf PW, Cornejo Pontelli M, Bloyet LM, Eckhaus MA, Mendoza MI, Whelan S, Verthelyi D. Manangeeswaran M, et al. Among authors: lewkowicz ap. Front Immunol. 2022 Jul 28;13:919815. doi: 10.3389/fimmu.2022.919815. eCollection 2022. Front Immunol. 2022. PMID: 35967447 Free PMC article.
Long-term persistence of infectious Zika virus: Inflammation and behavioral sequela in mice.
Ireland DDC, Manangeeswaran M, Lewkowicz AP, Engel K, Clark SM, Laniyan A, Sykes J, Lee HN, McWilliams IL, Kelley-Baker L, Tonelli LH, Verthelyi D. Ireland DDC, et al. Among authors: lewkowicz ap. PLoS Pathog. 2020 Dec 10;16(12):e1008689. doi: 10.1371/journal.ppat.1008689. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33301527 Free PMC article.
Characterization of the therapeutic effect of antibodies targeting the Ebola glycoprotein using a novel BSL2-compliant rVSVΔG-EBOV-GP infection model.
Lee HN, McWilliams IL, Lewkowicz AP, Engel K, Ireland DDC, Kelley-Baker L, Thacker S, Piccardo P, Manangeeswaran M, Verthelyi D. Lee HN, et al. Among authors: lewkowicz ap. Emerg Microbes Infect. 2021 Dec;10(1):2076-2089. doi: 10.1080/22221751.2021.1997075. Emerg Microbes Infect. 2021. PMID: 34674613 Free PMC article.
Neonatal Zika virus infection causes transient perineuronal net degradation.
Engel K, Lee HN, Tewari BP, Lewkowicz AP, Ireland DDC, Manangeeswaran M, Verthelyi D. Engel K, et al. Among authors: lewkowicz ap. Front Cell Neurosci. 2023 Jul 11;17:1187425. doi: 10.3389/fncel.2023.1187425. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37496706 Free PMC article.
Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeutics.
Lee HN, Xu B, Lewkowicz AP, Engel K, Kelley-Baker L, McWilliams IL, Ireland DDC, Kielczewski JL, Li J, Fariss RN, Campos MM, Baum A, Kyratsous C, Pascal K, Chan CC, Caspi RR, Manangeeswaran M, Verthelyi D. Lee HN, et al. Among authors: lewkowicz ap. EBioMedicine. 2024 May 31;104:105170. doi: 10.1016/j.ebiom.2024.105170. Online ahead of print. EBioMedicine. 2024. PMID: 38823088 Free article.