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The subdued post-boost spike-directed secondary IgG antibody response in Ugandan recipients of the Pfizer-BioNTech BNT162b2 vaccine has implications for local vaccination policies.
Ankunda V, Katende JS, Oluka GK, Sembera J, Baine C, Odoch G, Ejou P, Kato L; COVID-19 Immunoprofiling Team; Kaleebu P, Serwanga J. Ankunda V, et al. Among authors: odoch g. Front Immunol. 2024 Feb 16;15:1325387. doi: 10.3389/fimmu.2024.1325387. eCollection 2024. Front Immunol. 2024. PMID: 38469296 Free PMC article.
Sustained S-IgG and S-IgA antibodies to Moderna's mRNA-1273 vaccine in a Sub-Saharan African cohort suggests need for booster timing reconsiderations.
Serwanga J, Ankunda V, Katende JS, Baine C, Oluka GK, Odoch G, Nantambi H, Mugaba S, Namuyanja A, Ssali I, Ejou P, Kato L; COVID-19 Immunoprofiling Team; Musenero M, Kaleebu P. Serwanga J, et al. Among authors: odoch g. Front Immunol. 2024 Jan 31;15:1348905. doi: 10.3389/fimmu.2024.1348905. eCollection 2024. Front Immunol. 2024. PMID: 38357547 Free PMC article.
Sustained spike-specific IgG antibodies following CoronaVac (Sinovac) vaccination in sub-Saharan Africa, but increased breakthrough infections in baseline spike-naive individuals.
Sembera J, Baine C, Ankunda V, Katende JS, Oluka GK, Akoli CH, Kato L, Odoch G, Ejou P, Opio S, Musenero M; COVID-19 Immunoprofiling Team; Kaleebu P, Serwanga J. Sembera J, et al. Among authors: odoch g. Front Immunol. 2023 Nov 30;14:1255676. doi: 10.3389/fimmu.2023.1255676. eCollection 2023. Front Immunol. 2023. PMID: 38098482 Free PMC article.
Bacterial microbiome and host inflammatory gene expression in foreskin tissue.
Maust BS, Petkov S, Herrera C, Feng C, Brown BP, Lebina L, Opoka D, Ssemata A, Pillay N, Serwanga J, Seatlholo P, Namubiru P, Odoch G, Mugaba S, Seiphetlo T, Gray CM, Kaleebu P, Webb EL, Martinson N, Chiodi F, Fox J, Jaspan HB; CHAPS team. Maust BS, et al. Among authors: odoch g. Heliyon. 2023 Nov 14;9(11):e22145. doi: 10.1016/j.heliyon.2023.e22145. eCollection 2023 Nov. Heliyon. 2023. PMID: 38053902 Free PMC article.
Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trial.
Herrera C, Serwanga J, Else L, Limakatso L, Opoka D, Ssemata AS, Pillay AD, Namubiru P, Seiphetlo TB, Odoch G, Mugaba S, Seatlholo P, Alieu A, Penchala SD, Muhumuza R, Alinde B, Petkov S, O'Hagan K, Callebaut C, Seeley J, Weiss H, Khoo S, Chiodi F, Gray CM, Kaleebu P, Webb EL, Martinson N, Fox J; CHAPS. Herrera C, et al. Among authors: odoch g. EBioMedicine. 2023 Jul;93:104648. doi: 10.1016/j.ebiom.2023.104648. Epub 2023 Jun 14. EBioMedicine. 2023. PMID: 37327677 Free PMC article. Clinical Trial.
A randomized clinical trial of on-demand oral pre-exposure prophylaxis does not modulate lymphoid/myeloid HIV target cell density in the foreskin.
Rametse CL, Webb EL, Herrera C, Alinde B, Besethi A, Motaung B, Mbangiwa T, Leach L, Sebaa S, Pillay AAP, Seiphetlo TB, Malhangu B, Petkov S, Else L, Mugaba S, Namubiru P, Odoch G, Opoka D, Serwanga J, Ssemata AS, Kaleebu P, Khoo S, Lebina L, Martinson N, Chiodi F, Fox J, Gray CM; CHAPS consortium. Rametse CL, et al. Among authors: odoch g. AIDS. 2023 Sep 1;37(11):1651-1659. doi: 10.1097/QAD.0000000000003619. Epub 2023 Jun 6. AIDS. 2023. PMID: 37289572 Clinical Trial.
Seroprevalence and durability of antibody responses to AstraZeneca vaccination in Ugandans with prior mild or asymptomatic COVID-19: implications for vaccine policy.
Serwanga J, Baine C, Mugaba S, Ankunda V, Auma BO, Oluka GK, Kato L, Kitabye I, Sembera J, Odoch G, Ejou P, Nalumansi A, Gombe B, Musenero M, Kaleebu P. Serwanga J, et al. Among authors: odoch g. Front Immunol. 2023 May 2;14:1183983. doi: 10.3389/fimmu.2023.1183983. eCollection 2023. Front Immunol. 2023. PMID: 37205095 Free PMC article.
Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens.
Nantambi H, Sembera J, Ankunda V, Ssali I, Kalyebi AW, Oluka GK, Kato L, Ubaldo B, Kibengo F, Katende JS, Gombe B, Baine C, Odoch G, Mugaba S, Sande OJ; COVID-19 Immunoprofiling Team; Kaleebu P, Serwanga J. Nantambi H, et al. Among authors: odoch g. Front Immunol. 2023 Apr 19;14:1148877. doi: 10.3389/fimmu.2023.1148877. eCollection 2023. Front Immunol. 2023. PMID: 37153598 Free PMC article.
Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months.
Serwanga J, Ankunda V, Sembera J, Kato L, Oluka GK, Baine C, Odoch G, Kayiwa J, Auma BO, Jjuuko M, Nsereko C, Cotten M, Onyachi N, Muwanga M, Lutalo T, Fox J, Musenero M, Kaleebu P; COVID-19 Immunoprofiling Team. Serwanga J, et al. Among authors: odoch g. Front Immunol. 2023 Mar 16;14:1152522. doi: 10.3389/fimmu.2023.1152522. eCollection 2023. Front Immunol. 2023. PMID: 37006272 Free PMC article.
Optimisation and Validation of a conventional ELISA and cut-offs for detecting and quantifying anti-SARS-CoV-2 Spike, RBD, and Nucleoprotein IgG, IgM, and IgA antibodies in Uganda.
Oluka GK, Namubiru P, Kato L, Ankunda V, Gombe B, Cotten M; COVID-19 Immunoprofiling Team; Musenero M, Kaleebu P, Fox J, Serwanga J. Oluka GK, et al. Front Immunol. 2023 Mar 14;14:1113194. doi: 10.3389/fimmu.2023.1113194. eCollection 2023. Front Immunol. 2023. PMID: 36999017 Free PMC article.
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