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Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype.
Int J Mol Sci. 2022 Aug 8;23(15):8797. doi: 10.3390/ijms23158797.
Int J Mol Sci. 2022.
PMID: 35955932
Free PMC article.
Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists.
Chałupnik P, Vialko A, Pickering DS, Nielsen B, Bay Y, Skov Kristensen A, Hinkkanen M, Szczepańska K, Karcz T, Latacz G, Johansen TN, Szymańska E.
Chałupnik P, et al. Among authors: bay y.
ChemMedChem. 2023 Sep 15;18(18):e202300278. doi: 10.1002/cmdc.202300278. Epub 2023 Jul 20.
ChemMedChem. 2023.
PMID: 37387321
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Mechanism and site of action of big dynorphin on ASIC1a.
Borg CB, Braun N, Heusser SA, Bay Y, Weis D, Galleano I, Lund C, Tian W, Haugaard-Kedström LM, Bennett EP, Lynagh T, Strømgaard K, Andersen J, Pless SA.
Borg CB, et al. Among authors: bay y.
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7447-7454. doi: 10.1073/pnas.1919323117. Epub 2020 Mar 12.
Proc Natl Acad Sci U S A. 2020.
PMID: 32165542
Free PMC article.
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The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.
Bay Y, Egeberg Jeppesen M, Frydenvang K, Francotte P, Pirotte B, Pickering DS, Kristensen AS, Kastrup JS.
Bay Y, et al.
FEBS Lett. 2024 Apr;598(7):743-757. doi: 10.1002/1873-3468.14824. Epub 2024 Feb 18.
FEBS Lett. 2024.
PMID: 38369668
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Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.
Bay Y, Venskutonytė R, Frantsen SM, Thorsen TS, Musgaard M, Frydenvang K, Francotte P, Pirotte B, Biggin PC, Kristensen AS, Boesen T, Pickering DS, Gajhede M, Kastrup JS.
Bay Y, et al.
FEBS J. 2024 Apr;291(7):1506-1529. doi: 10.1111/febs.17046. Epub 2024 Feb 23.
FEBS J. 2024.
PMID: 38145505
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Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.
Francotte P, Bay Y, Goffin E, Colson T, Lesenfants C, Dorosz J, Laulumaa S, Fraikin P, de Tullio P, Beaufour C, Botez I, Pickering DS, Frydenvang K, Danober L, Kristensen AS, Kastrup JS, Pirotte B.
Francotte P, et al. Among authors: bay y.
Eur J Med Chem. 2024 Jan 15;264:116036. doi: 10.1016/j.ejmech.2023.116036. Epub 2023 Dec 9.
Eur J Med Chem. 2024.
PMID: 38101041
Free article.
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A new graphical format to communicate treatment effects to patients-A web-based randomized controlled trial.
Kasper J, van de Roemer A, Pöttgen J, Rahn A, Backhus I, Bay Y, Köpke S, Heesen C.
Kasper J, et al. Among authors: bay y.
Health Expect. 2017 Aug;20(4):797-804. doi: 10.1111/hex.12522. Epub 2016 Dec 16.
Health Expect. 2017.
PMID: 27981688
Free PMC article.
Clinical Trial.
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