Lathrop RH - Search Results

1

Discovery of compounds that reactivate p53 mutants in vitro and in vivo.

Durairaj G, Demir Ö, Lim B, Baronio R, Tifrea D, Hall LV, DeForest JC, Lauinger L, Jebril Fallatah MM, Yu C, Bae H, Lin DW, Kim JK, Salehi F, Jang C, Qiao F, Lathrop RH, Huang L, Edwards R, Rychnovsky S, Amaro RE, Kaiser P. Durairaj G, et al. Among authors: lathrop rh. Cell Chem Biol. 2022 Sep 15;29(9):1381-1395.e13. doi: 10.1016/j.chembiol.2022.07.003. Epub 2022 Aug 10. Cell Chem Biol. 2022. PMID: 35948006 Free PMC article.

2

Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants.

Demir Ö, Baronio R, Salehi F, Wassman CD, Hall L, Hatfield GW, Chamberlin R, Kaiser P, Lathrop RH, Amaro RE. Demir Ö, et al. Among authors: lathrop rh. PLoS Comput Biol. 2011 Oct;7(10):e1002238. doi: 10.1371/journal.pcbi.1002238. Epub 2011 Oct 20. PLoS Comput Biol. 2011. PMID: 22028641 Free PMC article.

3

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53.

Wassman CD, Baronio R, Demir Ö, Wallentine BD, Chen CK, Hall LV, Salehi F, Lin DW, Chung BP, Hatfield GW, Richard Chamberlin A, Luecke H, Lathrop RH, Kaiser P, Amaro RE. Wassman CD, et al. Among authors: lathrop rh. Nat Commun. 2013;4:1407. doi: 10.1038/ncomms2361. Nat Commun. 2013. PMID: 23360998 Free PMC article.

4

Predicting positive p53 cancer rescue regions using Most Informative Positive (MIP) active learning.

Danziger SA, Baronio R, Ho L, Hall L, Salmon K, Hatfield GW, Kaiser P, Lathrop RH. Danziger SA, et al. Among authors: lathrop rh. PLoS Comput Biol. 2009 Sep;5(9):e1000498. doi: 10.1371/journal.pcbi.1000498. Epub 2008 Sep 4. PLoS Comput Biol. 2009. PMID: 19756158 Free PMC article.

5

All-codon scanning identifies p53 cancer rescue mutations.

Baronio R, Danziger SA, Hall LV, Salmon K, Hatfield GW, Lathrop RH, Kaiser P. Baronio R, et al. Among authors: lathrop rh. Nucleic Acids Res. 2010 Nov;38(20):7079-88. doi: 10.1093/nar/gkq571. Epub 2010 Jun 25. Nucleic Acids Res. 2010. PMID: 20581117 Free PMC article.

6

CHOPER filters enable rare mutation detection in complex mutagenesis populations by next-generation sequencing.

Salehi F, Baronio R, Idrogo-Lam R, Vu H, Hall LV, Kaiser P, Lathrop RH. Salehi F, et al. Among authors: lathrop rh. PLoS One. 2015 Feb 18;10(2):e0116877. doi: 10.1371/journal.pone.0116877. eCollection 2015. PLoS One. 2015. PMID: 25692681 Free PMC article.

7

HB tag modules for PCR-based gene tagging and tandem affinity purification in Saccharomyces cerevisiae.

Tagwerker C, Zhang H, Wang X, Larsen LS, Lathrop RH, Hatfield GW, Auer B, Huang L, Kaiser P. Tagwerker C, et al. Among authors: lathrop rh. Yeast. 2006 Jun;23(8):623-32. doi: 10.1002/yea.1380. Yeast. 2006. PMID: 16823883

8

Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.

Danziger SA, Swamidass SJ, Zeng J, Dearth LR, Lu Q, Chen JH, Cheng J, Hoang VP, Saigo H, Luo R, Baldi P, Brachmann RK, Lathrop RH. Danziger SA, et al. Among authors: lathrop rh. IEEE/ACM Trans Comput Biol Bioinform. 2006 Apr-Jun;3(2):114-25. doi: 10.1109/TCBB.2006.22. IEEE/ACM Trans Comput Biol Bioinform. 2006. PMID: 17048398 Free PMC article.

9

Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants.

Danziger SA, Zeng J, Wang Y, Brachmann RK, Lathrop RH. Danziger SA, et al. Among authors: lathrop rh. Bioinformatics. 2007 Jul 1;23(13):i104-14. doi: 10.1093/bioinformatics/btm166. Bioinformatics. 2007. PMID: 17646286 Free PMC article.

10

Mechanism of U insertion RNA editing in trypanosome mitochondria: the bimodal TUTase activity of the core complex.

Ringpis GE, Aphasizheva I, Wang X, Huang L, Lathrop RH, Hatfield GW, Aphasizhev R. Ringpis GE, et al. Among authors: lathrop rh. J Mol Biol. 2010 Jun 25;399(5):680-95. doi: 10.1016/j.jmb.2010.03.050. Epub 2010 Apr 1. J Mol Biol. 2010. PMID: 20362585 Free PMC article.

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