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Page 1
Discovery of compounds that reactivate p53 mutants in vitro and in vivo.
Durairaj G, Demir Ö, Lim B, Baronio R, Tifrea D, Hall LV, DeForest JC, Lauinger L, Jebril Fallatah MM, Yu C, Bae H, Lin DW, Kim JK, Salehi F, Jang C, Qiao F, Lathrop RH, Huang L, Edwards R, Rychnovsky S, Amaro RE, Kaiser P. Durairaj G, et al. Among authors: deforest jc. Cell Chem Biol. 2022 Sep 15;29(9):1381-1395.e13. doi: 10.1016/j.chembiol.2022.07.003. Epub 2022 Aug 10. Cell Chem Biol. 2022. PMID: 35948006 Free PMC article.
Total Synthesis of (-)-Himeradine A.
Burtea A, DeForest J, Li X, Rychnovsky SD. Burtea A, et al. Angew Chem Int Ed Engl. 2019 Nov 4;58(45):16193-16197. doi: 10.1002/anie.201910129. Epub 2019 Sep 25. Angew Chem Int Ed Engl. 2019. PMID: 31491044
Synthetic Approaches to the New Drugs Approved during 2019.
Flick AC, Leverett CA, Ding HX, McInturff E, Fink SJ, Mahapatra S, Carney DW, Lindsey EA, DeForest JC, France SP, Berritt S, Bigi-Botterill SV, Gibson TS, Liu Y, O'Donnell CJ. Flick AC, et al. Among authors: deforest jc. J Med Chem. 2021 Apr 8;64(7):3604-3657. doi: 10.1021/acs.jmedchem.1c00208. Epub 2021 Mar 30. J Med Chem. 2021. PMID: 33783211 Review.
Synthetic Approaches to New Drugs Approved during 2018.
Flick AC, Leverett CA, Ding HX, McInturff E, Fink SJ, Helal CJ, DeForest JC, Morse PD, Mahapatra S, O'Donnell CJ. Flick AC, et al. Among authors: deforest jc. J Med Chem. 2020 Oct 8;63(19):10652-10704. doi: 10.1021/acs.jmedchem.0c00345. Epub 2020 May 22. J Med Chem. 2020. PMID: 32338902
Synthetic Approaches to the New Drugs Approved During 2020.
Flick AC, Leverett CA, Ding HX, McInturff EL, Fink SJ, Mahapatra S, Carney DW, Lindsey EA, DeForest JC, France SP, Berritt S, Bigi-Botterill SV, Gibson TS, Watson RB, Liu Y, O'Donnell CJ. Flick AC, et al. Among authors: deforest jc. J Med Chem. 2022 Jul 28;65(14):9607-9661. doi: 10.1021/acs.jmedchem.2c00710. Epub 2022 Jul 14. J Med Chem. 2022. PMID: 35833579 Review.
Synthetic Approaches to the New Drugs Approved During 2022.
France SP, Lindsey EA, McInturff EL, Berritt S, Carney DW, DeForest JC, Fink SJ, Flick AC, Gibson TS, Gray K, Johnson AM, Leverett CA, Liu Y, Mahapatra S, Watson RB. France SP, et al. Among authors: deforest jc. J Med Chem. 2024 Mar 28;67(6):4376-4418. doi: 10.1021/acs.jmedchem.3c02374. Epub 2024 Mar 15. J Med Chem. 2024. PMID: 38488755 Review.
Synthetic Approaches to the New Drugs Approved During 2021.
McInturff EL, France SP, Leverett CA, Flick AC, Lindsey EA, Berritt S, Carney DW, DeForest JC, Ding HX, Fink SJ, Gibson TS, Gray K, Hubbell AK, Johnson AM, Liu Y, Mahapatra S, McAlpine IJ, Watson RB, O'Donnell CJ. McInturff EL, et al. Among authors: deforest jc. J Med Chem. 2023 Aug 10;66(15):10150-10201. doi: 10.1021/acs.jmedchem.3c00501. Epub 2023 Aug 1. J Med Chem. 2023. PMID: 37528515 Review.