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Discovery of compounds that reactivate p53 mutants in vitro and in vivo.
Durairaj G, Demir Ö, Lim B, Baronio R, Tifrea D, Hall LV, DeForest JC, Lauinger L, Jebril Fallatah MM, Yu C, Bae H, Lin DW, Kim JK, Salehi F, Jang C, Qiao F, Lathrop RH, Huang L, Edwards R, Rychnovsky S, Amaro RE, Kaiser P. Durairaj G, et al. Among authors: baronio r. Cell Chem Biol. 2022 Sep 15;29(9):1381-1395.e13. doi: 10.1016/j.chembiol.2022.07.003. Epub 2022 Aug 10. Cell Chem Biol. 2022. PMID: 35948006 Free PMC article.
All-codon scanning identifies p53 cancer rescue mutations.
Baronio R, Danziger SA, Hall LV, Salmon K, Hatfield GW, Lathrop RH, Kaiser P. Baronio R, et al. Nucleic Acids Res. 2010 Nov;38(20):7079-88. doi: 10.1093/nar/gkq571. Epub 2010 Jun 25. Nucleic Acids Res. 2010. PMID: 20581117 Free PMC article.
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.
Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL. Rottner AK, et al. Among authors: baronio r. Nat Genet. 2023 Jan;55(1):54-65. doi: 10.1038/s41588-022-01261-2. Epub 2022 Dec 21. Nat Genet. 2023. PMID: 36543916 Free PMC article.
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, Monteiro OP, Bennett JM, Baronio R, Müller S, Daniels DL, Méndez J, Knapp S, Brennan PE, Dixon DJ. Clark PG, et al. Among authors: baronio r. Angew Chem Weinheim Bergstr Ger. 2015 May 18;127(21):6315-6319. doi: 10.1002/ange.201501394. Epub 2015 Apr 13. Angew Chem Weinheim Bergstr Ger. 2015. PMID: 27346896 Free PMC article.
18 results