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Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.
PLoS Negl Trop Dis. 2022 Aug 8;16(8):e0010636. doi: 10.1371/journal.pntd.0010636. eCollection 2022 Aug.
PLoS Negl Trop Dis. 2022.
PMID: 35939501
Free PMC article.
Clinical Trial.
Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections.
Warfield KL, Alonzi DS, Hill JC, Caputo AT, Roversi P, Kiappes JL, Sheets N, Duchars M, Dwek RA, Biggins J, Barnard D, Shresta S, Treston AM, Zitzmann N.
Warfield KL, et al. Among authors: duchars m.
J Med Chem. 2020 Apr 23;63(8):4205-4214. doi: 10.1021/acs.jmedchem.0c00067. Epub 2020 Apr 15.
J Med Chem. 2020.
PMID: 32227946
Item in Clipboard
Efficacy and immunogenicity of single-dose AdVAV intranasal anthrax vaccine compared to anthrax vaccine absorbed in an aerosolized spore rabbit challenge model.
Krishnan V, Andersen BH, Shoemaker C, Sivko GS, Tordoff KP, Stark GV, Zhang J, Feng T, Duchars M, Roberts MS.
Krishnan V, et al. Among authors: duchars m.
Clin Vaccine Immunol. 2015 Apr;22(4):430-9. doi: 10.1128/CVI.00690-14. Epub 2015 Feb 11.
Clin Vaccine Immunol. 2015.
PMID: 25673303
Free PMC article.
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Recombinant protective antigen anthrax vaccine improves survival when administered as a postexposure prophylaxis countermeasure with antibiotic in the New Zealand white rabbit model of inhalation anthrax.
Leffel EK, Bourdage JS, Williamson ED, Duchars M, Fuerst TR, Fusco PC.
Leffel EK, et al. Among authors: duchars m.
Clin Vaccine Immunol. 2012 Aug;19(8):1158-64. doi: 10.1128/CVI.00240-12. Epub 2012 Jun 13.
Clin Vaccine Immunol. 2012.
PMID: 22695155
Free PMC article.
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Immunogenicity of recombinant protective antigen and efficacy against aerosol challenge with anthrax.
Williamson ED, Hodgson I, Walker NJ, Topping AW, Duchars MG, Mott JM, Estep J, Lebutt C, Flick-Smith HC, Jones HE, Li H, Quinn CP.
Williamson ED, et al. Among authors: duchars mg.
Infect Immun. 2005 Sep;73(9):5978-87. doi: 10.1128/IAI.73.9.5978-5987.2005.
Infect Immun. 2005.
PMID: 16113318
Free PMC article.
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Predictive models and correlates of protection for testing biodefence vaccines.
Williamson ED, Duchars MG, Kohberger R.
Williamson ED, et al. Among authors: duchars mg.
Expert Rev Vaccines. 2010 May;9(5):527-37. doi: 10.1586/erv.10.22.
Expert Rev Vaccines. 2010.
PMID: 20450327
Review.
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Transcriptional regulation of denitrification genes in Paracoccus denitrificans.
Hinsley AP, Duchars MG, Spiro S.
Hinsley AP, et al. Among authors: duchars mg.
Biochem Soc Trans. 1995 Feb;23(1):126S. doi: 10.1042/bst023126s.
Biochem Soc Trans. 1995.
PMID: 7758688
No abstract available.
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