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Page 1
Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
Iijima D, Sugama H, Takahashi Y, Hirai M, Togashi Y, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T. Iijima D, et al. Among authors: takedomi k. J Med Chem. 2022 Aug 25;65(16):10882-10897. doi: 10.1021/acs.jmedchem.2c00834. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35939295
Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist.
Iijima T, Katoh M, Takedomi K, Yamamoto Y, Akatsuka H, Shirata N, Nishi A, Takakuwa M, Watanabe Y, Munakata H, Koyama N, Ikeda T, Iguchi T, Kato H, Kikkawa K, Kawaguchi T. Iijima T, et al. Among authors: takedomi k. J Med Chem. 2022 Jun 23;65(12):8127-8143. doi: 10.1021/acs.jmedchem.2c00402. Epub 2022 Jun 2. J Med Chem. 2022. PMID: 35652647
Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
Iijima D, Sugama H, Awai N, Takahashi Y, Togashi Y, Takebe T, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T. Iijima D, et al. Among authors: takedomi k. ACS Med Chem Lett. 2022 Aug 1;13(8):1351-1357. doi: 10.1021/acsmedchemlett.2c00280. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978678 Free PMC article.
Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2.
Sakakibara R, Sasaki W, Onda Y, Yamaguchi M, Ushirogochi H, Hiraga Y, Sato K, Nishio M, Egi Y, Takedomi K, Shimizu H, Ohbora T, Akahoshi F. Sakakibara R, et al. Among authors: takedomi k. J Med Chem. 2018 Jul 12;61(13):5594-5608. doi: 10.1021/acs.jmedchem.8b00328. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29878770
Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety.
Koizumi Y, Tanaka Y, Matsumura T, Kadoh Y, Miyoshi H, Hongu M, Takedomi K, Kotera J, Sasaki T, Taniguchi H, Watanabe Y, Takakuwa M, Kojima K, Baba N, Nakamura I, Kawanishi E. Koizumi Y, et al. Among authors: takedomi k. Bioorg Med Chem. 2019 Aug 1;27(15):3440-3450. doi: 10.1016/j.bmc.2019.06.021. Epub 2019 Jun 19. Bioorg Med Chem. 2019. PMID: 31235264
Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.
Bakir F, Kher S, Pannala M, Wilson N, Nguyen T, Sircar I, Takedomi K, Fukushima C, Zapf J, Xu K, Zhang SH, Liu J, Morera L, Schneider L, Sakurai N, Jack R, Cheng JF. Bakir F, et al. Among authors: takedomi k. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3473-9. doi: 10.1016/j.bmcl.2007.03.076. Epub 2007 Mar 27. Bioorg Med Chem Lett. 2007. PMID: 17416521
Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor.
Kadoh Y, Miyoshi H, Matsumura T, Tanaka Y, Hongu M, Kimura M, Takedomi K, Omori K, Kotera J, Sasaki T, Kobayashi T, Taniguchi H, Watanabe Y, Kojima K, Sakamoto T, Himiyama T, Kawanishi E. Kadoh Y, et al. Among authors: takedomi k. Chem Pharm Bull (Tokyo). 2018;66(3):243-250. doi: 10.1248/cpb.c17-00783. Chem Pharm Bull (Tokyo). 2018. PMID: 29491258 Free article.
30 results