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AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling.
Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko E. Ferrarotto R, et al. Among authors: pearson at. Cell Death Dis. 2022 Aug 5;13(8):678. doi: 10.1038/s41419-022-05133-9. Cell Death Dis. 2022. PMID: 35931701 Free PMC article.
Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma.
Schubert AD, Channah Broner E, Agrawal N, London N, Pearson A, Gupta A, Wali N, Seiwert TY, Wheelan S, Lingen M, Macleod K, Allen H, Chatterjee A, Vassiliki S, Gaykalova D, Hoque MO, Sidransky D, Suresh K, Izumchenko E. Schubert AD, et al. Cancer Lett. 2020 Feb 28;471:49-60. doi: 10.1016/j.canlet.2019.12.006. Epub 2019 Dec 10. Cancer Lett. 2020. PMID: 31830557 Free PMC article.
Survival of salivary gland cancer stem cells requires mTOR signaling.
Andrade NP, Warner KA, Zhang Z, Pearson AT, Mantesso A, Guimaraēs DM, Altemani A, Mariano FV, Nunes FD, Nör JE. Andrade NP, et al. Among authors: pearson at. Cell Death Dis. 2021 Jan 21;12(1):108. doi: 10.1038/s41419-021-03391-7. Cell Death Dis. 2021. PMID: 33479203 Free PMC article.
Wnt-β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression.
Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Quandt J, et al. Among authors: pearson at. Nat Immunol. 2021 Apr;22(4):471-484. doi: 10.1038/s41590-021-00889-2. Epub 2021 Mar 4. Nat Immunol. 2021. PMID: 33664518 Free PMC article.
COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity.
Naumov V, Putin E, Pushkov S, Kozlova E, Romantsov K, Kalashnikov A, Galkin F, Tihonova N, Shneyderman A, Galkin E, Zinkevich A, Cope SM, Sethuraman R, Oprea TI, Pearson AT, Tay S, Agrawal N, Dubovenko A, Vanhaelen Q, Ozerov I, Aliper A, Izumchenko E, Zhavoronkov A. Naumov V, et al. Among authors: pearson at. PLoS Comput Biol. 2021 Jul 14;17(7):e1009183. doi: 10.1371/journal.pcbi.1009183. eCollection 2021 Jul. PLoS Comput Biol. 2021. PMID: 34260589 Free PMC article.
Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma.
Broner EC, Trujillo JA, Korzinkin M, Subbannayya T, Agrawal N, Ozerov IV, Zhavoronkov A, Rooper L, Kotlov N, Shen L, Pearson AT, Rosenberg AJ, Savage PA, Mishra V, Chatterjee A, Sidransky D, Izumchenko E. Broner EC, et al. Among authors: pearson at. Front Oncol. 2021 Jul 16;11:677051. doi: 10.3389/fonc.2021.677051. eCollection 2021. Front Oncol. 2021. PMID: 34336664 Free PMC article.
A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma.
Ghantous Y, Omar M, Broner EC, Agrawal N, Pearson AT, Rosenberg AJ, Mishra V, Singh A, El-Naaj IA, Savage PA, Sidransky D, Marchionni L, Izumchenko E. Ghantous Y, et al. Among authors: pearson at. Int J Cancer. 2022 Feb 1;150(3):450-460. doi: 10.1002/ijc.33828. Epub 2021 Oct 14. Int J Cancer. 2022. PMID: 34569064 Free PMC article.
Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience.
Rosenberg AJ, Agrawal N, Pearson A, Gooi Z, Blair E, Cursio J, Juloori A, Ginat D, Howard A, Chin J, Kochanny S, Foster C, Cipriani N, Lingen M, Izumchenko E, Seiwert TY, Haraf D, Vokes EE. Rosenberg AJ, et al. Oral Oncol. 2021 Nov;122:105566. doi: 10.1016/j.oraloncology.2021.105566. Epub 2021 Oct 18. Oral Oncol. 2021. PMID: 34662771 Free PMC article. Clinical Trial.
111 results