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NHERF family and NHE3 regulation.
Donowitz M, Cha B, Zachos NC, Brett CL, Sharma A, Tse CM, Li X. Donowitz M, et al. J Physiol. 2005 Aug 15;567(Pt 1):3-11. doi: 10.1113/jphysiol.2005.090399. Epub 2005 May 19. J Physiol. 2005. PMID: 15905209 Free PMC article. Review.
Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site.
Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M. Chen T, et al. Among authors: donowitz m. J Biol Chem. 2015 Jan 23;290(4):1952-65. doi: 10.1074/jbc.M114.590174. Epub 2014 Dec 5. J Biol Chem. 2015. PMID: 25480791 Free PMC article.
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Duan T, et al. Among authors: donowitz m. FASEB J. 2019 Oct;33(10):10924-10934. doi: 10.1096/fj.201901166R. Epub 2019 Jul 3. FASEB J. 2019. PMID: 31268738 Free PMC article.
These results implicate CFTR activation in the colon as a major prosecretory mechanism of CDCA, a bile acid implicated in BAD, and support the potential therapeutic efficacy of CFTR inhibition in bile acid-associated diarrheas.-Duan, T., Cil, O., Tse, C. M., Sarker, R., Li …
These results implicate CFTR activation in the colon as a major prosecretory mechanism of CDCA, a bile acid implicated in BAD, and support t …
NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells.
Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. Chen T, et al. Among authors: donowitz m. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C737-C748. doi: 10.1152/ajpcell.00351.2018. Epub 2019 Jul 31. Am J Physiol Cell Physiol. 2019. PMID: 31365292 Free PMC article.
322 results