Keohane C - Search Results

1

N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, Legenski K, Matico R, Shaffer P, Simonnet Y, Tanner A, Wang CY, Wang W, Attar R, Edwards JP, Kuduk SD. Cisar JS, et al. Among authors: keohane c. J Med Chem. 2022 Aug 25;65(16):11241-11256. doi: 10.1021/acs.jmedchem.2c00788. Epub 2022 Aug 4. J Med Chem. 2022. PMID: 35925768

2

Total synthesis and biological investigation of (-)-promysalin.

Steele AD, Knouse KW, Keohane CE, Wuest WM. Steele AD, et al. J Am Chem Soc. 2015 Jun 17;137(23):7314-7. doi: 10.1021/jacs.5b04767. Epub 2015 Jun 5. J Am Chem Soc. 2015. PMID: 26024439

3

Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase.

Keohane CE, Steele AD, Fetzer C, Khowsathit J, Van Tyne D, Moynié L, Gilmore MS, Karanicolas J, Sieber SA, Wuest WM. Keohane CE, et al. J Am Chem Soc. 2018 Feb 7;140(5):1774-1782. doi: 10.1021/jacs.7b11212. Epub 2018 Jan 24. J Am Chem Soc. 2018. PMID: 29300464 Free PMC article.

4

Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440.

Giglio KM, Keohane CE, Stodghill PV, Steele AD, Fetzer C, Sieber SA, Filiatrault MJ, Wuest WM. Giglio KM, et al. Among authors: keohane ce. ACS Infect Dis. 2018 Aug 10;4(8):1179-1187. doi: 10.1021/acsinfecdis.8b00041. Epub 2018 Jun 5. ACS Infect Dis. 2018. PMID: 29801413 Free PMC article.

5

Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase.

Post SJ, Keohane CE, Rossiter LM, Kaplan AR, Khowsathit J, Matuska K, Karanicolas J, Wuest WM. Post SJ, et al. ACS Infect Dis. 2020 Jun 12;6(6):1372-1377. doi: 10.1021/acsinfecdis.0c00024. Epub 2020 Apr 14. ACS Infect Dis. 2020. PMID: 32286041 Free PMC article.

6

A new class of synthetic retinoid antibiotics effective against bacterial persisters.

Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E. Kim W, et al. Nature. 2018 Apr 5;556(7699):103-107. doi: 10.1038/nature26157. Epub 2018 Mar 28. Nature. 2018. PMID: 29590091 Free PMC article.

7

Correction to "Target-Based Design of Promysalin Analogs Identifies a New Putative Binding Cleft in Succinate Dehydrogenase".

Post SJ, Keohane CE, Rossiter LM, Kaplan AR, Khowsathit J, Matuska K, Karanicolas J, Wuest WM. Post SJ, et al. Among authors: keohane ce. ACS Infect Dis. 2022 Jul 8;8(7):1376. doi: 10.1021/acsinfecdis.2c00256. Epub 2022 Jun 6. ACS Infect Dis. 2022. PMID: 35801300 No abstract available.

8

Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity.

Steele AD, Keohane CE, Knouse KW, Rossiter SE, Williams SJ, Wuest WM. Steele AD, et al. J Am Chem Soc. 2016 May 11;138(18):5833-6. doi: 10.1021/jacs.6b03373. Epub 2016 Apr 28. J Am Chem Soc. 2016. PMID: 27096543 Free PMC article.

9

Incidence and impact of non-canonical JAK2 p.(Val617Phe) mutations in myeloproliferative neoplasm molecular diagnostics.

Patchell D, Keohane C, O'Shea S, Langabeer SE. Patchell D, et al. Among authors: keohane c. J Clin Pathol. 2024 May 17:jcp-2023-209276. doi: 10.1136/jcp-2023-209276. Online ahead of print. J Clin Pathol. 2024. PMID: 38772616 No abstract available.

10

The psychological needs of adolescents and young adults with a diagnosis of myeloproliferative neoplasms: a systematic scoping review of the literature.

Houlihan T, Fortune DG, Keohane C, Richards HL. Houlihan T, et al. Among authors: keohane c. Leuk Lymphoma. 2024 May;65(5):679-683. doi: 10.1080/10428194.2024.2313618. Epub 2024 Feb 7. Leuk Lymphoma. 2024. PMID: 38324010 No abstract available.

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