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Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury.
Valentijn FA, Knoppert SN, Marquez-Exposito L, Rodrigues-Diez RR, Pissas G, Tang J, Tejedor-Santamaria L, Broekhuizen R, Samarakoon R, Eleftheriadis T, Goldschmeding R, Nguyen TQ, Ruiz-Ortega M, Falke LL. Valentijn FA, et al. Among authors: samarakoon r. Kidney Int. 2022 Dec;102(6):1305-1319. doi: 10.1016/j.kint.2022.06.030. Epub 2022 Jul 31. Kidney Int. 2022. PMID: 35921911 Free article.
Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair.
Samarakoon R, Rehfuss A, Khakoo NS, Falke LL, Dobberfuhl AD, Helo S, Overstreet JM, Goldschmeding R, Higgins PJ. Samarakoon R, et al. FASEB J. 2016 Oct;30(10):3308-3320. doi: 10.1096/fj.201500105R. Epub 2016 Jun 21. FASEB J. 2016. PMID: 27328942 Free PMC article.
These findings establish PPM1A as a novel repressor of the SMAD3 pathway in renal fibrosis and as a new therapeutic target in patients with chronic kidney disease.-Samarakoon, R., Rehfuss, A., Khakoo, N. S., Falke, L. L., Dobberfuhl, A. D., Helo, S., Overstreet, J. …
These findings establish PPM1A as a novel repressor of the SMAD3 pathway in renal fibrosis and as a new therapeutic target in patients with …
Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype.
Anorga S, Overstreet JM, Falke LL, Tang J, Goldschmeding RG, Higgins PJ, Samarakoon R. Anorga S, et al. Among authors: samarakoon r. FASEB J. 2018 May;32(5):2644-2657. doi: 10.1096/fj.201700722R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29298862 Free PMC article.
-Anorga, S., Overstreet, J. M., Falke, L. L., Tang, J., Goldschmeding, R. G., Higgins, P. J., Samarakoon, R. Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype....
-Anorga, S., Overstreet, J. M., Falke, L. L., Tang, J., Goldschmeding, R. G., Higgins, P. J., Samarakoon, R. Deregulati …
Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways.
Patel S, Tang J, Overstreet JM, Anorga S, Lian F, Arnouk A, Goldschmeding R, Higgins PJ, Samarakoon R. Patel S, et al. Among authors: samarakoon r. FASEB J. 2019 Sep;33(9):9797-9810. doi: 10.1096/fj.201802489RR. Epub 2019 May 16. FASEB J. 2019. PMID: 31095421 Free PMC article.
., Overstreet, J. M., Anorga, S., Lian, F., Arnouk, A., Goldschmeding, R., Higgins, P. J., Samarakoon, R. Rac-GTPase promotes fibrotic TGF-beta1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways....
., Overstreet, J. M., Anorga, S., Lian, F., Arnouk, A., Goldschmeding, R., Higgins, P. J., Samarakoon, R. Rac-GTPase pr …
TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications.
Higgins CE, Tang J, Mian BM, Higgins SP, Gifford CC, Conti DJ, Meldrum KK, Samarakoon R, Higgins PJ. Higgins CE, et al. Among authors: samarakoon r. FASEB J. 2019 Oct;33(10):10596-10606. doi: 10.1096/fj.201900943R. Epub 2019 Jul 6. FASEB J. 2019. PMID: 31284746 Free PMC article. Review.
., Higgins, S. P., Gifford, C. C., Conti, D. J., Meldrum, K. K., Samarakoon, R., Higgins, P. J. TGF-beta1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications....
., Higgins, S. P., Gifford, C. C., Conti, D. J., Meldrum, K. K., Samarakoon, R., Higgins, P. J. TGF-beta1-p53 cooperativity re …
47 results