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IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells.
Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, Cagnard N, Carpentier W, Tang Q, Bluestone J, Chatenoud L, Klatzmann D, Salomon BL, Piaggio E. Grinberg-Bleyer Y, et al. Among authors: klatzmann d. J Exp Med. 2010 Aug 30;207(9):1871-8. doi: 10.1084/jem.20100209. Epub 2010 Aug 2. J Exp Med. 2010. PMID: 20679400 Free PMC article.
Self-specific memory regulatory T cells protect embryos at implantation in mice.
Chen T, Darrasse-Jèze G, Bergot AS, Courau T, Churlaud G, Valdivia K, Strominger JL, Ruocco MG, Chaouat G, Klatzmann D. Chen T, et al. Among authors: klatzmann d. J Immunol. 2013 Sep 1;191(5):2273-81. doi: 10.4049/jimmunol.1202413. Epub 2013 Aug 2. J Immunol. 2013. PMID: 23913969 Free PMC article.
Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer.
Churlaud G, Jimenez V, Ruberte J, Amadoudji Zin M, Fourcade G, Gottrand G, Casana E, Lambrecht B, Bellier B, Piaggio E, Bosch F, Klatzmann D. Churlaud G, et al. Among authors: klatzmann d. Clin Immunol. 2014 Apr;151(2):114-26. doi: 10.1016/j.clim.2014.02.003. Epub 2014 Feb 19. Clin Immunol. 2014. PMID: 24576619
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.
Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D. Rosenzwajg M, et al. Among authors: klatzmann d. J Autoimmun. 2015 Apr;58:48-58. doi: 10.1016/j.jaut.2015.01.001. Epub 2015 Jan 26. J Autoimmun. 2015. PMID: 25634360 Free PMC article. Clinical Trial.
Treatment of Uveitis by In Situ Administration of Ex Vivo-Activated Polyclonal Regulatory T Cells.
Grégoire S, Terrada C, Martin GH, Fourcade G, Baeyens A, Marodon G, Fisson S, Billiard F, Lucas B, Tadayoni R, Béhar-Cohen F, Levacher B, Galy A, LeHoang P, Klatzmann D, Bodaghi B, Salomon BL. Grégoire S, et al. Among authors: klatzmann d. J Immunol. 2016 Mar 1;196(5):2109-18. doi: 10.4049/jimmunol.1501723. Epub 2016 Jan 29. J Immunol. 2016. PMID: 26826251
373 results