Kir2 inward rectification-controlled precise and dynamic balances between Kir2 and HCN currents initiate pacemaking activity.
Chen K, Zuo D, Wang SY, Chen H.
Chen K, et al. Among authors: chen h.
FASEB J. 2018 Jun;32(6):3047-3057. doi: 10.1096/fj.201701260R. Epub 2018 Jan 12.
FASEB J. 2018.
PMID: 29401592
Free PMC article.
In this study, we created human embryonic kidney (HEK) 293 cells that show pacemaking activity through heterologous expression of strong inward rectifier K(+) subfamily 2 isoform 1 (Kir2.1) channels, hyperpolarization-activated cyclic nucleotide-gated isoform 2 (HCN2) nons …
In this study, we created human embryonic kidney (HEK) 293 cells that show pacemaking activity through heterologous expression of strong inw …