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Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
Darwish S, Ghazy E, Heimburg T, Herp D, Zeyen P, Salem-Altintas R, Ridinger J, Robaa D, Schmidtkunz K, Erdmann F, Schmidt M, Romier C, Jung M, Oehme I, Sippl W. Darwish S, et al. Among authors: ridinger j. Int J Mol Sci. 2022 Jul 7;23(14):7535. doi: 10.3390/ijms23147535. Int J Mol Sci. 2022. PMID: 35886887 Free PMC article.
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
Morgen M, Steimbach RR, Géraldy M, Hellweg L, Sehr P, Ridinger J, Witt O, Oehme I, Herbst-Gervasoni CJ, Osko JD, Porter NJ, Christianson DW, Gunkel N, Miller AK. Morgen M, et al. Among authors: ridinger j. ChemMedChem. 2020 Jul 3;15(13):1163-1174. doi: 10.1002/cmdc.202000149. Epub 2020 May 13. ChemMedChem. 2020. PMID: 32348628 Free PMC article.
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.
Ecker J, Thatikonda V, Sigismondo G, Selt F, Valinciute G, Oehme I, Müller C, Buhl JL, Ridinger J, Usta D, Qin N, van Tilburg CM, Herold-Mende C, Remke M, Sahm F, Westermann F, Kool M, Wechsler-Reya RJ, Chavez L, Krijgsveld J, Jäger N, Pfister SM, Witt O, Milde T. Ecker J, et al. Among authors: ridinger j. Neuro Oncol. 2021 Feb 25;23(2):226-239. doi: 10.1093/neuonc/noaa191. Neuro Oncol. 2021. PMID: 32822486 Free PMC article.
Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma.
Müller M, Rösch L, Najafi S, Gatzweiler C, Ridinger J, Gerloff XF, Jones DTW, Baßler J, Kreth S, Stainczyk S, Frese K, Meder B, Westermann F, Milde T, Peterziel H, Witt O, Oehme I. Müller M, et al. Among authors: ridinger j. Cancers (Basel). 2021 Sep 5;13(17):4476. doi: 10.3390/cancers13174476. Cancers (Basel). 2021. PMID: 34503286 Free PMC article.
26 results