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Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Kang JB, Chen L, Leng XJ, Wang JJ, Cheng Y, Wu SH, Ma YY, Yang LJ, Cao YH, Yang X, Tong ZJ, Wu JZ, Wang YB, Zhou H, Liu JC, Ding N, Dai WC, Yu YC, Xue X, Sun SL, Dai XB, Chang L, Wang XL, Li NG, Shi ZH. Kang JB, et al. Among authors: xue x. Bioorg Med Chem. 2022 Sep 15;70:116937. doi: 10.1016/j.bmc.2022.116937. Epub 2022 Jul 16. Bioorg Med Chem. 2022. PMID: 35863236
Discovery of 4-(4-aminophenyl)-6-phenylisoxazolo[3,4-b]pyridine-3-amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia.
Wang QX, Wang YB, Sha JK, Zhou H, Liu JC, Wu JZ, Tong ZJ, Cai J, Chen ZJ, Zhang CQ, Zheng XR, Wang JJ, Wang XL, Xue X, Yu YC, Ding N, Leng XJ, Dai WC, Sun SL, Chang L, Li NG, Shi ZH. Wang QX, et al. Among authors: xue x. Drug Dev Res. 2023 Apr;84(2):296-311. doi: 10.1002/ddr.22032. Epub 2023 Jan 16. Drug Dev Res. 2023. PMID: 36644989
5,160 results