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Page 1
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
Hill MD, Fang H, Norris D, Delucca GV, Huang H, DeBenedetto M, Quesnelle C, Schmitz WD, Tokarski JS, Sheriff S, Yan C, Fanslau C, Haarhoff Z, Huang C, Kramer M, Madari S, Menard K, Monereau L, Morrison J, Raghavan N, Shields EE, Simmermacher-Mayer J, Sinz M, Tye CK, Westhouse R, Xie C, Zhang H, Zhang L, Zvyaga T, Lee F, Gavai AV, Degnan AP. Hill MD, et al. Among authors: schmitz wd. ACS Med Chem Lett. 2022 Jul 5;13(7):1165-1171. doi: 10.1021/acsmedchemlett.2c00219. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859878 Free PMC article.
In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Hartz RA, Ahuja VT, Rafalski M, Schmitz WD, Brenner AB, Denhart DJ, Ditta JL, Deskus JA, Yue EW, Arvanitis AG, Lelas S, Li YW, Molski TF, Wong H, Grace JE, Lentz KA, Li J, Lodge NJ, Zaczek R, Combs AP, Olson RE, Mattson RJ, Bronson JJ, Macor JE. Hartz RA, et al. Among authors: schmitz wd. J Med Chem. 2009 Jul 23;52(14):4161-72. doi: 10.1021/jm900302q. J Med Chem. 2009. PMID: 19552436
Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Hartz RA, Ahuja VT, Arvanitis AG, Rafalski M, Yue EW, Denhart DJ, Schmitz WD, Ditta JL, Deskus JA, Brenner AB, Hobbs FW, Payne J, Lelas S, Li YW, Molski TF, Mattson GK, Peng Y, Wong H, Grace JE, Lentz KA, Qian-Cutrone J, Zhuo X, Shu YZ, Lodge NJ, Zaczek R, Combs AP, Olson RE, Bronson JJ, Mattson RJ, Macor JE. Hartz RA, et al. Among authors: schmitz wd. J Med Chem. 2009 Jul 23;52(14):4173-91. doi: 10.1021/jm900301y. J Med Chem. 2009. PMID: 19552437
5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.
Schmitz WD, Brenner AB, Bronson JJ, Ditta JL, Griffin CR, Li YW, Lodge NJ, Molski TF, Olson RE, Zhuo X, Macor JE. Schmitz WD, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3579-83. doi: 10.1016/j.bmcl.2010.04.121. Epub 2010 May 17. Bioorg Med Chem Lett. 2010. PMID: 20483614
Total synthesis of marine natural products driven by novel structure, potent biological activity, and/or synthetic methodology.
Romo D, Rzasa RM, Schmitz WD, Yang J, Cohn ST, Buchler IP, Shea HA, Park K, Langenhan JM, Messerschmidt NB, Cox MM. Romo D, et al. Among authors: schmitz wd. Ernst Schering Res Found Workshop. 2000;(32):103-48. doi: 10.1007/978-3-662-04042-3_4. Ernst Schering Res Found Workshop. 2000. PMID: 11077607 Review. No abstract available.
The Synthesis of Streptogramin Antibiotics: (-)-Griseoviridin and Its C-8 Epimer Financial support has been provided by the National Institutes of Health (NIH). We thank the NIH for financial support of this study and Drs. Russell Linderman, Donald Walker, Ronald Spohn, and Enrico Marcantoni for their assistance in various stages of this effort.
Dvorak CA, Schmitz WD, Poon DJ, Pryde DC, Lawson JP, Amos RA, Meyers AI. Dvorak CA, et al. Among authors: schmitz wd. Angew Chem Int Ed Engl. 2000 May;39(9):1664-1666. doi: 10.1002/(sici)1521-3773(20000502)39:9<1664::aid-anie1664>3.0.co;2-#. Angew Chem Int Ed Engl. 2000. PMID: 10820470 No abstract available.