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Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy.
Yang J, Grafton F, Ranjbarvaziri S, Budan A, Farshidfar F, Cho M, Xu E, Ho J, Maddah M, Loewke KE, Medina J, Sperandio D, Patel S, Hoey T, Mandegar MA. Yang J, et al. Among authors: ho j. Sci Transl Med. 2022 Jul 6;14(652):eabl5654. doi: 10.1126/scitranslmed.abl5654. Epub 2022 Jul 6. Sci Transl Med. 2022. PMID: 35857625
AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy.
Wu I, Zeng A, Greer-Short A, Aycinena JA, Tefera AE, Shenwai R, Farshidfar F, Van Pell M, Xu E, Reid C, Rodriguez N, Lim B, Chung TW, Woods J, Scott A, Jones S, Dee-Hoskins C, Gutierrez CG, Madariaga J, Robinson K, Hatter Y, Butler R, Steltzer S, Ho J, Priest JR, Song X, Jing F, Green K, Ivey KN, Hoey T, Yang J, Yang ZJ. Wu I, et al. Among authors: ho j. Commun Med (Lond). 2024 Mar 18;4(1):38. doi: 10.1038/s43856-024-00450-w. Commun Med (Lond). 2024. PMID: 38499690 Free PMC article.
Deep learning of left atrial structure and function provides link to atrial fibrillation risk.
Pirruccello JP, Di Achille P, Choi SH, Rämö JT, Khurshid S, Nekoui M, Jurgens SJ, Nauffal V, Kany S; FinnGen; Ng K, Friedman SF, Batra P, Lunetta KL, Palotie A, Philippakis AA, Ho JE, Lubitz SA, Ellinor PT. Pirruccello JP, et al. Among authors: ho je. Nat Commun. 2024 May 21;15(1):4304. doi: 10.1038/s41467-024-48229-w. Nat Commun. 2024. PMID: 38773065 Free PMC article.
ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.
Maxwell MB, Hom-Tedla MS, Yi J, Li S, Rivera SA, Yu J, Burns MJ, McRae HM, Stevenson BT, Coakley KE, Ho J, Gastelum KB, Bell JC, Jones AC, Eskander RN, Dykhuizen EC, Shadel GS, Kaech SM, Hargreaves DC. Maxwell MB, et al. Among authors: ho j. Cell. 2024 May 9:S0092-8674(24)00451-3. doi: 10.1016/j.cell.2024.04.025. Online ahead of print. Cell. 2024. PMID: 38754421
5,008 results