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Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
Petersson C, Zhou X, Berghausen J, Cebrian D, Davies M, DeMent K, Eddershaw P, Riedmaier AE, Leblanc AF, Manveski N, Marathe P, Mavroudis PD, McDougall R, Parrott N, Reichel A, Rotter C, Tess D, Volak LP, Xiao G, Yang Z, Baker J. Petersson C, et al. Among authors: davies m. AAPS J. 2022 Jul 19;24(5):85. doi: 10.1208/s12248-022-00735-9. AAPS J. 2022. PMID: 35854202 Review.
AZD4625 is a Potent and Selective Inhibitor of KRASG12C.
Chakraborty A, Hanson L, Robinson D, Lewis H, Bickerton S, Davies M, Polanski R, Whiteley R, Koers A, Atkinson J, Baker T, Del Barco Barrantes I, Ciotta G, Kettle JG, Magiera L, Martins CP, Peter A, Wigmore E, Underwood Z, Cosulich S, Niedbala M, Ross S. Chakraborty A, et al. Among authors: davies m. Mol Cancer Ther. 2022 Oct 7;21(10):1535-1546. doi: 10.1158/1535-7163.MCT-22-0241. Mol Cancer Ther. 2022. PMID: 35930755 Free PMC article.
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Kinneer K, Wortmann P, Cooper ZA, Dickinson NJ, Masterson L, Cailleau T, Hutchinson I, Vijayakrishnan B, McFarlane M, Ball K, Davies M, Lewis A, Huang Y, Rosenbaum AI, Yuan J, Chesebrough J, Anderton J, Monks N, Novick S, Wang J, Dimasi N, Christie RJ, Sabol D, Tosto FA, Wallez Y, Leo E, Albertella MR, Staniszewska AD, Tice DA, Howard PW, Luheshi N, Sapra P. Kinneer K, et al. Among authors: davies m. Clin Cancer Res. 2023 Mar 14;29(6):1086-1101. doi: 10.1158/1078-0432.CCR-22-2630. Clin Cancer Res. 2023. PMID: 36355054
Radiation in Combination with Immune Checkpoint Blockade and DNA Damage Response Inhibitors in Mice: Dosage Optimization in MC38 Syngeneic Tumors via Modelling and Simulation.
Hodson D, Mistry H, Yates J, Farrington P, Staniszewska A, Guzzetti S, Davies M, Aarons L, Ogungbenro K. Hodson D, et al. Among authors: davies m. J Pharmacol Exp Ther. 2023 Oct;387(1):44-54. doi: 10.1124/jpet.122.001572. Epub 2023 Jun 22. J Pharmacol Exp Ther. 2023. PMID: 37348964
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.
Kettle JG, Bagal SK, Bickerton S, Bodnarchuk MS, Boyd S, Breed J, Carbajo RJ, Cassar DJ, Chakraborty A, Cosulich S, Cumming I, Davies M, Davies NL, Eatherton A, Evans L, Feron L, Fillery S, Gleave ES, Goldberg FW, Hanson L, Harlfinger S, Howard M, Howells R, Jackson A, Kemmitt P, Lamont G, Lamont S, Lewis HJ, Liu L, Niedbala MJ, Phillips C, Polanski R, Raubo P, Robb G, Robinson DM, Ross S, Sanders MG, Tonge M, Whiteley R, Wilkinson S, Yang J, Zhang W. Kettle JG, et al. Among authors: davies nl, davies m. J Med Chem. 2022 May 12;65(9):6940-6952. doi: 10.1021/acs.jmedchem.2c00369. Epub 2022 Apr 26. J Med Chem. 2022. PMID: 35471939
Preservation of healthy lean body mass and function during weight loss.
Wilkinson TJ, Papamargaritis D, King JA, Sargeant JA, Sutcliffe C, Baker LA, Taheri S, Yates T, Davies MJ. Wilkinson TJ, et al. Among authors: davies mj. Clin Obes. 2024 May 23:e12683. doi: 10.1111/cob.12683. Online ahead of print. Clin Obes. 2024. PMID: 38783586 No abstract available.
Remote sensing-based mangrove blue carbon assessment in the Asia-Pacific: A systematic review.
Roy AD, Pitumpe Arachchige PS, Watt MS, Kale A, Davies M, Heng JE, Daneil R, Galgamuwa GAP, Moussa LG, Timsina K, Ewane EB, Rogers K, Hendy I, Edwards-Jones A, de Miguel S, Burt JA, Ali T, Sidik F, Abdullah M, Pandi Selvam P, Jaafar WSWM, Alawatte I, Doaemo W, Cardil A, Mohan M. Roy AD, et al. Among authors: davies m. Sci Total Environ. 2024 May 19:173270. doi: 10.1016/j.scitotenv.2024.173270. Online ahead of print. Sci Total Environ. 2024. PMID: 38772491 Review.
6,922 results