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CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo.
Ostedgaard LS, Zabner J, Vermeer DW, Rokhlina T, Karp PH, Stecenko AA, Randak C, Welsh MJ. Ostedgaard LS, et al. Among authors: karp ph. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3093-8. doi: 10.1073/pnas.261714599. Epub 2002 Feb 19. Proc Natl Acad Sci U S A. 2002. PMID: 11854474 Free PMC article.
Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR.
Farmen SL, Karp PH, Ng P, Palmer DJ, Koehler DR, Hu J, Beaudet AL, Zabner J, Welsh MJ. Farmen SL, et al. Among authors: karp ph. Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L1123-30. doi: 10.1152/ajplung.00049.2005. Epub 2005 Aug 5. Am J Physiol Lung Cell Mol Physiol. 2005. PMID: 16085675 Free article.
Processing and function of CFTR-DeltaF508 are species-dependent.
Ostedgaard LS, Rogers CS, Dong Q, Randak CO, Vermeer DW, Rokhlina T, Karp PH, Welsh MJ. Ostedgaard LS, et al. Among authors: karp ph. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15370-5. doi: 10.1073/pnas.0706974104. Epub 2007 Sep 14. Proc Natl Acad Sci U S A. 2007. PMID: 17873061 Free PMC article.
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ. Rogers CS, et al. Among authors: karp ph. Science. 2008 Sep 26;321(5897):1837-41. doi: 10.1126/science.1163600. Science. 2008. PMID: 18818360 Free PMC article.
55 results