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Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.
Kankanala J, Wang Y, Geraghty RJ, Wang Z. Kankanala J, et al. ChemMedChem. 2018 Aug 20;13(16):1658-1663. doi: 10.1002/cmdc.201800283. Epub 2018 Jul 20. ChemMedChem. 2018. PMID: 29968426
However, inhibitors of the endonuclease activity of the C terminus of pUL89 (pUL89-C) were unknown before our recently characterized hydroxypyridonecarboxylic acid (HPCA) hit 7 r (1-(3-chloro-4-fluorobenzyl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxylic acid; numbered as 10 k …
However, inhibitors of the endonuclease activity of the C terminus of pUL89 (pUL89-C) were unknown before our recently characterized hydroxy …
Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.
Wang L, Casey MC, Vernekar SKV, Sahani RL, Kankanala J, Kirby KA, Du H, Hachiya A, Zhang H, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Wang L, et al. Among authors: kankanala j. Eur J Med Chem. 2020 Oct 15;204:112626. doi: 10.1016/j.ejmech.2020.112626. Epub 2020 Jul 19. Eur J Med Chem. 2020. PMID: 32814250 Free PMC article.
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
Ribeiro CJA, Kankanala J, Xie J, Williams J, Aihara H, Wang Z. Ribeiro CJA, et al. Among authors: kankanala j. Bioorg Med Chem Lett. 2019 Jan 15;29(2):257-261. doi: 10.1016/j.bmcl.2018.11.044. Epub 2018 Nov 22. Bioorg Med Chem Lett. 2019. PMID: 30522956 Free PMC article.
30 results