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Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture.
Commun Biol. 2022 Jul 8;5(1):681. doi: 10.1038/s42003-022-03613-4.
Commun Biol. 2022.
PMID: 35804152
Free PMC article.
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Münch J.
Wettstein L, et al. Among authors: knaff pm.
Nat Commun. 2021 Mar 19;12(1):1726. doi: 10.1038/s41467-021-21972-0.
Nat Commun. 2021.
PMID: 33741941
Free PMC article.
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Interfering with Host Proteases in SARS-CoV-2 Entry as a Promising Therapeutic Strategy.
Müller P, Maus H, Hammerschmidt SJ, Knaff PM, Mailänder V, Schirmeister T, Kersten C.
Müller P, et al. Among authors: knaff pm.
Curr Med Chem. 2022;29(4):635-665. doi: 10.2174/0929867328666210526111318.
Curr Med Chem. 2022.
PMID: 34042026
Review.
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Structure-Based Design of High-Affinity and Selective Peptidomimetic Hepsin Inhibitors.
Knaff PM, Müller P, Kersten C, Wettstein L, Münch J, Landfester K, Mailänder V.
Knaff PM, et al.
Biomacromolecules. 2022 Jun 13;23(6):2236-2242. doi: 10.1021/acs.biomac.1c01011. Epub 2022 May 20.
Biomacromolecules. 2022.
PMID: 35593713
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From In Silico to Experimental Validation: Tailoring Peptide Substrates for a Serine Protease.
Knaff PM, Kersten C, Willbold R, Champanhac C, Crespy D, Wittig R, Landfester K, Mailänder V.
Knaff PM, et al.
Biomacromolecules. 2020 Apr 13;21(4):1636-1643. doi: 10.1021/acs.biomac.0c00240. Epub 2020 Apr 2.
Biomacromolecules. 2020.
PMID: 32191450
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