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GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia.
Liu L, Patnana PK, Xie X, Frank D, Nimmagadda SC, Su M, Zhang D, Koenig T, Rosenbauer F, Liebmann M, Klotz L, Xu W, Vorwerk J, Neumann F, Hüve J, Unger A, Okun JG, Opalka B, Khandanpour C. Liu L, et al. Among authors: khandanpour c. Leukemia. 2022 Sep;36(9):2196-2207. doi: 10.1038/s41375-022-01635-9. Epub 2022 Jul 8. Leukemia. 2022. PMID: 35804097 Free PMC article.
Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia.
Geyh S, Rodríguez-Paredes M, Jäger P, Khandanpour C, Cadeddu RP, Gutekunst J, Wilk CM, Fenk R, Zilkens C, Hermsen D, Germing U, Kobbe G, Lyko F, Haas R, Schroeder T. Geyh S, et al. Among authors: khandanpour c. Leukemia. 2016 Mar;30(3):683-91. doi: 10.1038/leu.2015.325. Epub 2015 Nov 25. Leukemia. 2016. PMID: 26601782
GFI1 as a novel prognostic and therapeutic factor for AML/MDS.
Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewski JP, Möröy T, Khandanpour C. Hönes JM, et al. Among authors: khandanpour c. Leukemia. 2016 Jun;30(6):1237-45. doi: 10.1038/leu.2016.11. Epub 2016 Feb 5. Leukemia. 2016. PMID: 26847026
GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome.
Botezatu L, Michel LC, Makishima H, Schroeder T, Germing U, Haas R, van der Reijden B, Marneth AE, Bergevoet SM, Jansen JH, Przychodzen B, Wlodarski M, Niemeyer C, Platzbecker U, Ehninger G, Unnikrishnan A, Beck D, Pimanda J, Hellström-Lindberg E, Malcovati L, Boultwood J, Pellagatti A, Papaemmanuil E, Le Coutre P, Kaeda J, Opalka B, Möröy T, Dührsen U, Maciejewski J, Khandanpour C. Botezatu L, et al. Among authors: khandanpour c. Exp Hematol. 2016 Jul;44(7):590-595.e1. doi: 10.1016/j.exphem.2016.04.001. Epub 2016 Apr 11. Exp Hematol. 2016. PMID: 27080012 Free PMC article.
Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner.
Al-Matary YS, Botezatu L, Opalka B, Hönes JM, Lams RF, Thivakaran A, Schütte J, Köster R, Lennartz K, Schroeder T, Haas R, Dührsen U, Khandanpour C. Al-Matary YS, et al. Among authors: khandanpour c. Haematologica. 2016 Oct;101(10):1216-1227. doi: 10.3324/haematol.2016.143180. Epub 2016 Jul 7. Haematologica. 2016. PMID: 27390361 Free PMC article.
Enforced GFI1 expression impedes human and murine leukemic cell growth.
Hönes JM, Thivakaran A, Botezatu L, Patnana P, Castro SVDC, Al-Matary YS, Schütte J, Fischer KBI, Vassen L, Görgens A, Dührsen U, Giebel B, Khandanpour C. Hönes JM, et al. Among authors: khandanpour c. Sci Rep. 2017 Nov 16;7(1):15720. doi: 10.1038/s41598-017-15866-9. Sci Rep. 2017. PMID: 29147018 Free PMC article.
Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome.
Thivakaran A, Botezatu L, Hönes JM, Schütte J, Vassen L, Al-Matary YS, Patnana P, Zeller A, Heuser M, Thol F, Gabdoulline R, Olberding N, Frank D, Suslo M, Köster R, Lennartz K, Görgens A, Giebel B, Opalka B, Dührsen U, Khandanpour C. Thivakaran A, et al. Among authors: khandanpour c. Haematologica. 2018 Apr;103(4):614-625. doi: 10.3324/haematol.2017.167288. Epub 2018 Jan 11. Haematologica. 2018. PMID: 29326122 Free PMC article.
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Barth J, Abou-El-Ardat K, Dalic D, Kurrle N, Maier AM, Mohr S, Schütte J, Vassen L, Greve G, Schulz-Fincke J, Schmitt M, Tosic M, Metzger E, Bug G, Khandanpour C, Wagner SA, Lübbert M, Jung M, Serve H, Schüle R, Berg T. Barth J, et al. Among authors: khandanpour c. Leukemia. 2019 Jun;33(6):1411-1426. doi: 10.1038/s41375-018-0375-7. Epub 2019 Jan 24. Leukemia. 2019. PMID: 30679800
66 results