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Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies.
Hammouda MM, Elmaaty AA, Nafie MS, Abdel-Motaal M, Mohamed NS, Tantawy MA, Belal A, Alnajjar R, Eldehna WM, Al-Karmalawy AA. Hammouda MM, et al. Among authors: eldehna wm. Bioorg Chem. 2022 Oct;127:105995. doi: 10.1016/j.bioorg.2022.105995. Epub 2022 Jun 30. Bioorg Chem. 2022. PMID: 35792315
Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.
Eldehna WM, Abou-Seri SM, El Kerdawy AM, Ayyad RR, Hamdy AM, Ghabbour HA, Ali MM, Abou El Ella DA. Eldehna WM, et al. Eur J Med Chem. 2016 May 4;113:50-62. doi: 10.1016/j.ejmech.2016.02.029. Epub 2016 Feb 15. Eur J Med Chem. 2016. PMID: 26922228
Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation.
Al-Ansary GH, Eldehna WM, Ghabbour HA, Al-Rashood STA, Al-Rashood KA, Eladwy RA, Al-Dhfyan A, Kabil MM, Abdel-Aziz HA. Al-Ansary GH, et al. Among authors: eldehna wm. J Enzyme Inhib Med Chem. 2017 Dec;32(1):986-991. doi: 10.1080/14756366.2017.1347166. J Enzyme Inhib Med Chem. 2017. PMID: 28726519 Free PMC article.
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.
Eldehna WM, Abo-Ashour MF, Nocentini A, Gratteri P, Eissa IH, Fares M, Ismael OE, Ghabbour HA, Elaasser MM, Abdel-Aziz HA, Supuran CT. Eldehna WM, et al. Eur J Med Chem. 2017 Oct 20;139:250-262. doi: 10.1016/j.ejmech.2017.07.073. Epub 2017 Aug 1. Eur J Med Chem. 2017. PMID: 28802125
197 results