Georg GI - Search Results

1

Physiological Characterization of the Transporter-Mediated Uptake of the Reversible Male Contraceptive H2-Gamendazole Across the Blood-Testis Barrier.

Hau RK, Tash JS, Georg GI, Wright SH, Cherrington NJ. Hau RK, et al. Among authors: georg gi. J Pharmacol Exp Ther. 2022 Sep;382(3):299-312. doi: 10.1124/jpet.122.001195. Epub 2022 Jul 2. J Pharmacol Exp Ther. 2022. PMID: 35779861 Free PMC article.

2

Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells.

Tash JS, Chakrasali R, Jakkaraj SR, Hughes J, Smith SK, Hornbaker K, Heckert LL, Ozturk SB, Hadden MK, Kinzy TG, Blagg BS, Georg GI. Tash JS, et al. Among authors: georg gi. Biol Reprod. 2008 Jun;78(6):1139-52. doi: 10.1095/biolreprod.107.062679. Epub 2008 Jan 23. Biol Reprod. 2008. PMID: 18218611

3

A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose.

Tash JS, Attardi B, Hild SA, Chakrasali R, Jakkaraj SR, Georg GI. Tash JS, et al. Among authors: georg gi. Biol Reprod. 2008 Jun;78(6):1127-38. doi: 10.1095/biolreprod.106.057810. Epub 2008 Jan 23. Biol Reprod. 2008. PMID: 18218612

4

Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases.

Lee JC, Francis S, Dutta D, Gupta V, Yang Y, Zhu JY, Tash JS, Schönbrunn E, Georg GI. Lee JC, et al. Among authors: georg gi. J Org Chem. 2012 Apr 6;77(7):3082-98. doi: 10.1021/jo202054g. Epub 2012 Mar 20. J Org Chem. 2012. PMID: 22432895 Free PMC article.

5

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.

Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, Georg GI. Schonbrunn E, et al. Among authors: georg gi. J Med Chem. 2013 May 23;56(10):3768-82. doi: 10.1021/jm301234k. Epub 2013 May 6. J Med Chem. 2013. PMID: 23600925 Free PMC article.

6

Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2.

Olesen SH, Ingles DJ, Zhu JY, Martin MP, Betzi S, Georg GI, Tash JS, Schönbrunn E. Olesen SH, et al. Among authors: georg gi. Molecules. 2015 Jan 19;20(1):1643-60. doi: 10.3390/molecules20011643. Molecules. 2015. PMID: 25608045 Free PMC article.

7

Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.

Gu X, Gupta V, Yang Y, Zhu JY, Carlson EJ, Kingsley C, Tash JS, Schönbrunn E, Hawkinson J, Georg GI. Gu X, et al. Among authors: georg gi. ChemMedChem. 2017 Dec 7;12(23):1977-1984. doi: 10.1002/cmdc.201700558. Epub 2017 Nov 24. ChemMedChem. 2017. PMID: 28975712 Free PMC article.

8

Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats.

Rautiola D, Maglalang PD, Cheryala N, Nelson KM, Georg GI, Fine JM, Svitak AL, Faltesek KA, Hanson LR, Mishra U, Coles LD, Cloyd JC, Siegel RA. Rautiola D, et al. Among authors: georg gi. J Pharmacol Exp Ther. 2019 Sep;370(3):796-805. doi: 10.1124/jpet.118.255943. Epub 2019 Mar 5. J Pharmacol Exp Ther. 2019. PMID: 30837282 Free PMC article.

9

N-Butyldeoxygalactonojirimycin Induces Reversible Infertility in Male CD Rats.

Gupta V, Hild SA, Jakkaraj SR, Carlson EJ, Wong HL, Allen CL, Georg GI, Tash JS. Gupta V, et al. Among authors: georg gi. Int J Mol Sci. 2019 Dec 31;21(1):301. doi: 10.3390/ijms21010301. Int J Mol Sci. 2019. PMID: 31906257 Free PMC article.

10

Tetrahydroindazole inhibitors of CDK2/cyclin complexes.

Lee JC, Hong KH, Becker A, Tash JS, Schönbrunn E, Georg GI. Lee JC, et al. Among authors: georg gi. Eur J Med Chem. 2021 Mar 15;214:113232. doi: 10.1016/j.ejmech.2021.113232. Epub 2021 Jan 31. Eur J Med Chem. 2021. PMID: 33550184 Free PMC article.

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