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A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity.
Queiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD. Queiroz DD, et al. Among authors: outeiro tf. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166475. doi: 10.1016/j.bbadis.2022.166475. Epub 2022 Jun 28. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35777688 Free article.
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF. Lázaro DF, et al. Among authors: outeiro tf. PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov. PLoS Genet. 2014. PMID: 25393002 Free PMC article.
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro TF, Eckermann K. Guerreiro PS, et al. Among authors: outeiro tf. Mol Neurobiol. 2016 Jul;53(5):3124-3135. doi: 10.1007/s12035-015-9209-z. Epub 2015 May 27. Mol Neurobiol. 2016. PMID: 26014385
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.
Oliveira LM, Falomir-Lockhart LJ, Botelho MG, Lin KH, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schüle B, Arndt-Jovin DJ, Jovin TM. Oliveira LM, et al. Among authors: outeiro tf. Cell Death Dis. 2015 Nov 26;6(11):e1994. doi: 10.1038/cddis.2015.318. Cell Death Dis. 2015. PMID: 26610207 Free PMC article.
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. Villar-Piqué A, et al. Among authors: outeiro tf. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. doi: 10.1073/pnas.1606791113. Epub 2016 Oct 5. Proc Natl Acad Sci U S A. 2016. PMID: 27708160 Free PMC article.
A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies.
Cukierman DS, Pinheiro AB, Castiñeiras-Filho SL, da Silva AS, Miotto MC, De Falco A, de P Ribeiro T, Maisonette S, da Cunha AL, Hauser-Davis RA, Landeira-Fernandez J, Aucélio RQ, Outeiro TF, Pereira MD, Fernández CO, Rey NA. Cukierman DS, et al. Among authors: outeiro tf. J Inorg Biochem. 2017 May;170:160-168. doi: 10.1016/j.jinorgbio.2017.02.020. Epub 2017 Feb 22. J Inorg Biochem. 2017. PMID: 28249224
329 results