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A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Su S, Xue Y, Sharov A, Zhang Y, Lee SK, Martindale JL, Li W, Ku WL, Zhao K, De S, Shen W, Sen P, Gorospe M, Xu D, Wang W. Su S, et al. Among authors: shen w. Nucleic Acids Res. 2022 Jul 8;50(12):7013-7033. doi: 10.1093/nar/gkac538. Nucleic Acids Res. 2022. PMID: 35748872 Free PMC article.
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.
Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D 3rd, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W. Xu D, et al. Among authors: shen w. Nat Neurosci. 2013 Sep;16(9):1238-47. doi: 10.1038/nn.3479. Epub 2013 Aug 4. Nat Neurosci. 2013. PMID: 23912945 Free PMC article.
RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.
Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D, Wang W. Ahmad M, et al. Among authors: shen w. Nucleic Acids Res. 2016 Jul 27;44(13):6335-49. doi: 10.1093/nar/gkw508. Epub 2016 Jun 1. Nucleic Acids Res. 2016. PMID: 27257063 Free PMC article.
Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.
Joo Y, Xue Y, Wang Y, McDevitt RA, Sah N, Bossi S, Su S, Lee SK, Peng W, Xie A, Zhang Y, Ding Y, Ku WL, Ghosh S, Fishbein K, Shen W, Spencer R, Becker K, Zhao K, Mattson MP, van Praag H, Sharov A, Wang W. Joo Y, et al. Among authors: shen w. Nat Commun. 2020 Jun 19;11(1):3143. doi: 10.1038/s41467-020-16884-4. Nat Commun. 2020. PMID: 32561719 Free PMC article.
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang W. Yan Z, et al. Among authors: shen w. Mol Cell. 2012 Jul 13;47(1):61-75. doi: 10.1016/j.molcel.2012.05.026. Epub 2012 Jun 14. Mol Cell. 2012. PMID: 22705371 Free PMC article.
9,042 results