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Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Poh AR, Love CG, Chisanga D, Steer JH, Baloyan D, Chopin M, Nutt S, Rautela J, Huntington ND, Etemadi N, O'Brien M, O'Keefe R, Ellies LG, Macri C, Mintern JD, Whitehead L, Gangadhara G, Boon L, Chand AL, Lowell CA, Shi W, Pixley FJ, Ernst M. Poh AR, et al. Among authors: ellies lg. Sci Adv. 2022 Jun 24;8(25):eabl7882. doi: 10.1126/sciadv.abl7882. Epub 2022 Jun 22. Sci Adv. 2022. PMID: 35731867 Free PMC article.
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.
Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Schmid MC, et al. Among authors: ellies lg. Cancer Cell. 2011 Jun 14;19(6):715-27. doi: 10.1016/j.ccr.2011.04.016. Cancer Cell. 2011. PMID: 21665146 Free PMC article.
Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations.
Aguilera TA, Elghonaimy EA, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong AC, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ. Aguilera TA, et al. Among authors: ellies lg. Clin Cancer Res. 2020 Jun 15;26(12):2972-2985. doi: 10.1158/1078-0432.CCR-19-4220. Epub 2020 Feb 25. Clin Cancer Res. 2020. PMID: 32098769 Free PMC article.
84 results