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Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Poh AR, Love CG, Chisanga D, Steer JH, Baloyan D, Chopin M, Nutt S, Rautela J, Huntington ND, Etemadi N, O'Brien M, O'Keefe R, Ellies LG, Macri C, Mintern JD, Whitehead L, Gangadhara G, Boon L, Chand AL, Lowell CA, Shi W, Pixley FJ, Ernst M. Poh AR, et al. Among authors: chand al. Sci Adv. 2022 Jun 24;8(25):eabl7882. doi: 10.1126/sciadv.abl7882. Epub 2022 Jun 22. Sci Adv. 2022. PMID: 35731867 Free PMC article.
The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.
Coulson R, Liew SH, Connelly AA, Yee NS, Deb S, Kumar B, Vargas AC, O'Toole SA, Parslow AC, Poh A, Putoczki T, Morrow RJ, Alorro M, Lazarus KA, Yeap EFW, Walton KL, Harrison CA, Hannan NJ, George AJ, Clyne CD, Ernst M, Allen AM, Chand AL. Coulson R, et al. Among authors: chand al. Oncotarget. 2017 Mar 21;8(12):18640-18656. doi: 10.18632/oncotarget.15553. Oncotarget. 2017. PMID: 28416734 Free PMC article.
Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
Thilakasiri P, Huynh J, Poh AR, Tan CW, Nero TL, Tran K, Parslow AC, Afshar-Sterle S, Baloyan D, Hannan NJ, Buchert M, Scott AM, Griffin MD, Hollande F, Parker MW, Putoczki TL, Ernst M, Chand AL. Thilakasiri P, et al. Among authors: chand al. EMBO Mol Med. 2019 Apr;11(4):e9539. doi: 10.15252/emmm.201809539. EMBO Mol Med. 2019. PMID: 30885958 Free PMC article.
Repurposing of drugs as STAT3 inhibitors for cancer therapy.
Thilakasiri PS, Dmello RS, Nero TL, Parker MW, Ernst M, Chand AL. Thilakasiri PS, et al. Among authors: chand al. Semin Cancer Biol. 2021 Jan;68:31-46. doi: 10.1016/j.semcancer.2019.09.022. Epub 2019 Nov 8. Semin Cancer Biol. 2021. PMID: 31711994 Review.
Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.
Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M. Poh AR, et al. Among authors: chand al. Cancer Immunol Res. 2020 Apr;8(4):428-435. doi: 10.1158/2326-6066.CIR-19-0623. Epub 2020 Jan 28. Cancer Immunol Res. 2020. PMID: 31992566 Free PMC article.
Host IL11 Signaling Suppresses CD4+ T cell-Mediated Antitumor Responses to Colon Cancer in Mice.
Huynh J, Baloyan D, Chisanga D, Shi W, O'Brien M, Afshar-Sterle S, Alorro M, Pang L, Williams DS, Parslow AC, Thilakasiri P, Eissmann MF, Boon L, Masson F, Chand AL, Ernst M. Huynh J, et al. Among authors: chand al. Cancer Immunol Res. 2021 Jul;9(7):735-747. doi: 10.1158/2326-6066.CIR-19-1023. Epub 2021 Apr 27. Cancer Immunol Res. 2021. PMID: 33906864
54 results