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Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Poh AR, Love CG, Chisanga D, Steer JH, Baloyan D, Chopin M, Nutt S, Rautela J, Huntington ND, Etemadi N, O'Brien M, O'Keefe R, Ellies LG, Macri C, Mintern JD, Whitehead L, Gangadhara G, Boon L, Chand AL, Lowell CA, Shi W, Pixley FJ, Ernst M. Poh AR, et al. Among authors: boon l. Sci Adv. 2022 Jun 24;8(25):eabl7882. doi: 10.1126/sciadv.abl7882. Epub 2022 Jun 22. Sci Adv. 2022. PMID: 35731867 Free PMC article.
Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.
Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M. Poh AR, et al. Among authors: boon l. Cancer Immunol Res. 2020 Apr;8(4):428-435. doi: 10.1158/2326-6066.CIR-19-0623. Epub 2020 Jan 28. Cancer Immunol Res. 2020. PMID: 31992566 Free PMC article.
Host IL11 Signaling Suppresses CD4+ T cell-Mediated Antitumor Responses to Colon Cancer in Mice.
Huynh J, Baloyan D, Chisanga D, Shi W, O'Brien M, Afshar-Sterle S, Alorro M, Pang L, Williams DS, Parslow AC, Thilakasiri P, Eissmann MF, Boon L, Masson F, Chand AL, Ernst M. Huynh J, et al. Among authors: boon l. Cancer Immunol Res. 2021 Jul;9(7):735-747. doi: 10.1158/2326-6066.CIR-19-1023. Epub 2021 Apr 27. Cancer Immunol Res. 2021. PMID: 33906864
Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.
Poh AR, O'Brien M, Chisanga D, He H, Baloyan D, Traichel J, Dijkstra C, Chopin M, Nutt S, Whitehead L, Boon L, Parkin A, Lowell C, Pajic M, Shi W, Nikfarjam M, Ernst M. Poh AR, et al. Among authors: boon l. Cell Rep. 2022 Oct 11;41(2):111479. doi: 10.1016/j.celrep.2022.111479. Cell Rep. 2022. PMID: 36223746 Free article.
Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma.
Galvani E, Mundra PA, Valpione S, Garcia-Martinez P, Smith M, Greenall J, Thakur R, Helmink B, Andrews MC, Boon L, Chester C, Gremel G, Hogan K, Mandal A, Zeng K, Banyard A, Ashton G, Cook M, Lorigan P, Wargo JA, Dhomen N, Marais R. Galvani E, et al. Among authors: boon l. Nat Commun. 2020 Feb 12;11(1):853. doi: 10.1038/s41467-020-14632-2. Nat Commun. 2020. PMID: 32051401 Free PMC article.
Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages.
Murgaski A, Kiss M, Van Damme H, Kancheva D, Vanmeerbeek I, Keirsse J, Hadadi E, Brughmans J, Arnouk SM, Hamouda AEI, Debraekeleer A, Bosteels V, Elkrim Y, Boon L, Hoves S, Vandamme N, Deschoemaeker S, Janssens S, Garg AD, Vande Velde G, Schmittnaegel M, Ries CH, Laoui D. Murgaski A, et al. Among authors: boon l. Cancer Res. 2022 Oct 17;82(20):3785-3801. doi: 10.1158/0008-5472.CAN-22-0094. Cancer Res. 2022. PMID: 35979635 Free PMC article.
Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells.
Nierkens S, den Brok MH, Garcia Z, Togher S, Wagenaars J, Wassink M, Boon L, Ruers TJ, Figdor CG, Schoenberger SP, Adema GJ, Janssen EM. Nierkens S, et al. Among authors: boon l. Cancer Res. 2011 Oct 15;71(20):6428-37. doi: 10.1158/0008-5472.CAN-11-2154. Epub 2011 Jul 25. Cancer Res. 2011. PMID: 21788345 Free PMC article.
Lack of CD24 expression in mice reduces the number of leukocytes in the colon.
Bretz NP, Salnikov AV, Doberstein K, Garbi N, Kloess V, Joumaa S, Naumov I, Boon L, Moldenhauer G, Arber N, Altevogt P. Bretz NP, et al. Among authors: boon l. Immunol Lett. 2014 Sep;161(1):140-8. doi: 10.1016/j.imlet.2014.06.004. Epub 2014 Jun 20. Immunol Lett. 2014. PMID: 24956310
583 results