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A small molecule inhibitor of HER3: a proof-of-concept study.
Colomba A, Fitzek M, George R, Weitsman G, Roberts S, Zanetti-Domingues L, Hirsch M, Rolfe DJ, Mehmood S, Madin A, Claus J, Kjaer S, Snijders AP, Ng T, Martin-Fernandez M, Smith DM, Parker PJ. Colomba A, et al. Biochem J. 2020 Sep 18;477(17):3329-3347. doi: 10.1042/BCJ20200496. Biochem J. 2020. PMID: 32815546 Free PMC article.
DNA damage alters nuclear mechanics through chromatin reorganization.
Dos Santos Á, Cook AW, Gough RE, Schilling M, Olszok NA, Brown I, Wang L, Aaron J, Martin-Fernandez ML, Rehfeldt F, Toseland CP. Dos Santos Á, et al. Nucleic Acids Res. 2021 Jan 11;49(1):340-353. doi: 10.1093/nar/gkaa1202. Nucleic Acids Res. 2021. PMID: 33330932 Free PMC article.
A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9.
Emmanouilidis I, Fili N, Cook AW, Hari-Gupta Y, Dos Santos Á, Wang L, Martin-Fernandez ML, Ellis PJI, Toseland CP. Emmanouilidis I, et al. Biomolecules. 2021 Feb 15;11(2):288. doi: 10.3390/biom11020288. Biomolecules. 2021. PMID: 33672015 Free PMC article.
Myosin VI regulates the spatial organisation of mammalian transcription initiation.
Hari-Gupta Y, Fili N, Dos Santos Á, Cook AW, Gough RE, Reed HCW, Wang L, Aaron J, Venit T, Wait E, Grosse-Berkenbusch A, Gebhardt JCM, Percipalle P, Chew TL, Martin-Fernandez M, Toseland CP. Hari-Gupta Y, et al. Nat Commun. 2022 Mar 15;13(1):1346. doi: 10.1038/s41467-022-28962-w. Nat Commun. 2022. PMID: 35292632 Free PMC article.
Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription.
Dos Santos Á, Rollins DE, Hari-Gupta Y, McArthur H, Du M, Ru SYZ, Pidlisna K, Stranger A, Lorgat F, Lambert D, Brown I, Howland K, Aaron J, Wang L, Ellis PJI, Chew TL, Martin-Fernandez M, Pyne ALB, Toseland CP. Dos Santos Á, et al. Nat Commun. 2023 May 18;14(1):2855. doi: 10.1038/s41467-023-38572-9. Nat Commun. 2023. PMID: 37202403 Free PMC article.
257 results